Cytokine and antibody production during murine leptospirosis
| Autor: | Márcia Marinho, Cíntia Rodrigues da Silva, Juliana Regina Peiró, Silvia Helena Venturoli Perri, Valéria Marçal Felix de Lima |
|---|---|
| Přispěvatelé: | Universidade Estadual Paulista (Unesp) |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
lcsh:Arctic medicine. Tropical medicine
lcsh:RC955-962 medicine.medical_treatment Leptospira interrogans serovar canicola Toxicology Microbiology Leptospira interrogans serovar Canicola Immune system lcsh:RA1190-1270 lcsh:Zoology medicine BALB/c mice leptospirosis lcsh:QL1-991 Bacteria (microorganisms) cellular immune response lcsh:Toxicology. Poisons biology Inoculation medicine.disease biology.organism_classification Leptospirosis cytokines Infectious Diseases Cytokine Immunology biology.protein Animal Science and Zoology Parasitology Tumor necrosis factor alpha Murinae Leptospira interrogans Antibody |
| Zdroj: | Journal of Venomous Animals and Toxins including Tropical Diseases v.12 n.4 2006 The Journal of venomous animals and toxins including tropical diseases Universidade Estadual Paulista (UNESP) instacron:UNESP Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 12, Iss 4, Pp 595-603 (2006) Journal of Venomous Animals and Toxins including Tropical Diseases, Volume: 12, Issue: 4, Pages: 595-603, Published: 2006 Scopus Repositório Institucional da UNESP |
| Popis: | Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:22:02Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:45:45Z : No. of bitstreams: 1 2-s2.0-33846284154.pdf: 177493 bytes, checksum: f3d34c124149d0220420f1e8bd4e52c4 (MD5) Made available in DSpace on 2014-05-27T11:22:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-11-01 The aim of the present study was to investigate the kinetics of humoral and cellular responses during leptospirosis. We observed that the presence of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) was associated with antibody production and bacterial recovery, and the compromising of both TNF-α and IL-6 in the immunopathogenesis of leptospirosis during an experimental infection of BALB/c mice inoculated with Leptospira interrogans serovar Canicola was verified. Results showed higher levels of TNF-α and IL-6 in the initial phase of infection, in which the greatest bacterial clearance was observed. However, when the bacterial recovery was compared with the kinetics of the production of antibodies, the results revealed a kinetics proportionally inverted to antibody production. This fact may be related to some inhibitory factor which could be responsible for the selective suppression of the cellular immune response. We concluded that during leptospirosis there was a greater mobilization of the cellular immune response activity, mainly in the initial phase of the infectious process, for posterior involvement of the humoral response, and that both TNF-α and IL-6 could be associated with the immunopathogenesis of the disease. Department of Animal Production and Health Araçatuba School of Dental Medicine São Paulo State University, Araçatuba, SP State Department for Clinic and Surgery and Animal Reproduction Araçatuba School of Dental Medicine São Paulo State University, Araçatuba, SP State , R. C. Pestana, 703, Bairro D. Amelia, 16050-690, Araçatuba, SP Department of Animal Production and Health Araçatuba School of Dental Medicine São Paulo State University, Araçatuba, SP State Department for Clinic and Surgery and Animal Reproduction Araçatuba School of Dental Medicine São Paulo State University, Araçatuba, SP State |
| Databáze: | OpenAIRE |
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