The association between serum levels of Th cytokines and rhinoconjunctivitis caused by methyltetrahydrophthalic anhydride
| Autor: | Tatsuya Takeshita, Kozo Yokota, K Yamaguchi, Kanehisa Morimoto |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Time Factors Immunology Population Immunoglobulin E Serology Interferon-gamma Occupational Exposure Immunopathology Respiratory Hypersensitivity Humans Immunology and Allergy Medicine education Interleukin 4 Conjunctivitis Allergic Retrospective Studies Rhinitis education.field_of_study Interleukin-13 biology business.industry Smoking Interleukin T-Lymphocytes Helper-Inducer Middle Aged Phthalic Anhydrides Interleukin 13 biology.protein Cytokines Female Interleukin-4 Antibody business |
| Zdroj: | Allergy. 53:803-807 |
| ISSN: | 0105-4538 |
| DOI: | 10.1111/j.1398-9995.1998.tb03978.x |
| Popis: | Background There are few epidemiologic studies on the association between serum levels of T helper (Th) cytokines and allergic symptoms caused by sensitizing agents. Methods A population of 147 workers from two condenser plants using epoxy resin with methyltetrahydrophthalic anhydride (MTHPA) underwent a questionnaire survey and serologic investigations. Total and MTHPA-specific IgE levels were measured by the Pharmacia CAP System, and serum levels of interleukin (IL)-4, IL-13, and interferon-gamma (IFN-γ) by enzyme immunoassay. Results A significant association was found between work-related eye and nasal symptoms and a range of atopic characteristics, including the frequency of positive specific IgE, specific and total IgE levels, and IL-4 levels. A positive correlation was observed between levels of IL-4 and IL-13 (r=0.42). Furthermore, multiple logistic analysis revealed significant contributions of specific IgE and I H3 to the work-related symptoms. A similar but nonsignificant association was also found for IL-4 (P=0.07). On the other hand, a multiple regression model with specific IgE levels as a dependent variable showed a significant association with total IgE, but not with IL-4, IL-13, and IFN-γ. Conclusions These results suggest that work-related eye and nasal symptoms are closely related to specific IgE antibodies, and that allergic responses, mediated by IgE, to MTHPA may lead to a shift in the balance between Thl and Th2 cells. |
| Databáze: | OpenAIRE |
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