Fat mass in lipid profile in young adults born preterm
| Autor: | Ruben H. Willemsen, Gerthe F. Kerkhof, Anita Hokken-Koelega, Petra E. Breukhoven |
|---|---|
| Přispěvatelé: | Pediatrics |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Clinical Biochemistry Abdominal Fat Subcutaneous Fat Context (language use) Disease Biochemistry Fat mass Cohort Studies Young Adult Endocrinology Pregnancy Risk Factors Internal medicine Medicine Humans Total fat Young adult Adiposity Dyslipidemias Netherlands medicine.diagnostic_test business.industry Biochemistry (medical) Infant Newborn Gestational age Overweight medicine.disease Lipids Cross-Sectional Studies Premature birth Cardiovascular Diseases Adult Children Premature Birth Female business Lipid profile Infant Premature |
| Zdroj: | Journal of Clinical Endocrinology and Metabolism, 97(4), 1294-1302. Endocrine Society |
| ISSN: | 1945-7197 0021-972X |
| Popis: | Associations between small size at birth and abnormal cardiovascular parameters in later life have been reported. It is, however, unknown whether the effect of a small size at birth on cardiovascular risk factors in later life is due to a small size for gestational age or due to prematurity. Due to advances in neonatal care, survival of preterm infants has significantly improved, and nowadays an increasing number of these children reach adulthood. It is, therefore, of increasing importance to assess the long-term effect of prematurity on determinants for cardiovascular disease.The aim of the study was to assess the long-term effects of gestational age and particularly preterm birth on lipid levels and fat mass in early adulthood.A cross-sectional study was conducted with 455 healthy subjects, aged 18 to 24 yr; 167 preterm subjects were compared with 288 full-term subjects.Total fat mass, trunk fat mass, and limb fat mass were determined by dual-energy x-ray absorptiometry. Furthermore, fasting lipid levels (total cholesterol, low-density lipoprotein, triglyceride, apolipoprotein B, lipoprotein a, high-density lipoprotein, and apolipoprotein A-I) were measured.Preterm subjects had a significantly higher percentage of total fat mass, trunk fat mass, and limb fat mass than subjects born term. Furthermore, preterm subjects had significantly lower serum lipoprotein a levels and higher apolipoprotein A-I levels than term subjects. Multiple linear regression analyses to assess the association between gestational age and fat mass and lipid levels showed similar results.In our cohort of 455 young adults, preterm birth was associated with more total fat mass, trunk fat, and limb fat mass but a relatively favorable lipid profile. |
| Databáze: | OpenAIRE |
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