Recurrence Patterns After Surgical Resection of Gastroenteropancreatic Neuroendocrine Tumors
| Autor: | Emily K. Bergsland, Jonathan R. Strosberg, Manisha H. Shah, Hilary Chan, Matthew H. Kulke, Michael A. Choti, Al B. Benson, Mark Bloomston, James C. Yao, Li Zhang, Eric K. Nakakura, Katherine Van Loon |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Oncology Databases Factual Outcome Assessment Endocrinology Diabetes and Metabolism Kaplan-Meier Estimate Neuroendocrine tumors New diagnosis 0302 clinical medicine Endocrinology Outcome Assessment Health Care 80 and over guidelines Cancer Aged 80 and over Middle Aged Primary tumor Colo-Rectal Cancer Neuroendocrine Tumors medicine.anatomical_structure Local 030220 oncology & carcinogenesis surveillance Female 030211 gastroenterology & hepatology Patient Safety Pancreas Adult Surgical resection medicine.medical_specialty recurrence Clinical Sciences MEDLINE Rectum Article Databases Young Adult 03 medical and health sciences Rare Diseases Stomach Neoplasms Internal medicine Intestinal Neoplasms Internal Medicine medicine Humans Factual Aged Gastroenterology & Hepatology Hepatology business.industry medicine.disease United States Pancreatic Neoplasms Health Care Neoplasm Recurrence Neoplasm Recurrence Local Digestive Diseases business |
| Zdroj: | Pancreas, vol 50, iss 4 Pancreas |
| ISSN: | 1536-4828 0885-3177 |
| Popis: | Objective Current National Comprehensive Cancer Network guidelines for gastroenteropancreatic neuroendocrine tumors (GEPNETs) recommend complete (R0) surgical resection of the primary tumor and metastases, if feasible. However, large multicenter studies of recurrence patterns of GEPNETs after resection have not been performed. Methods Patients 18 years or older who presented to 7 participating National Comprehensive Cancer Network institutions between 2004 and 2008 with a new diagnosis of a small bowel, pancreas, or colon/rectum neuroendocrine tumor (NET) and underwent R0 resection of the primary tumor, and synchronous metastases, if present, were included in this analysis. Descriptive statistics and Kaplan-Meier estimates were used to calculate recurrence rates and time-associated end points, respectively. Results Of 294 patients with GEPNETs, 50% were male, 88% were White, and 99% had Eastern Cooperative Oncology Group performance status 0 to 1. The median age was 55 years (range, 20-90). The median follow-up time from R0 resection was 62.1 months. Recurrence rates were 18% in small bowel NETs (n = 110), 26% in pancreatic NETs (n = 141), and 10% in colon/rectum NETs (n = 50). The frequency of surveillance imaging was highly variable. Conclusions R0 resection was associated with variable risk of recurrence across subtypes. Further research to inform refinement of guidelines for the appropriate duration of surveillance after R0 resection is needed. |
| Databáze: | OpenAIRE |
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