Karyotype evolution in a patient with down syndrome and acute leukemia following a congenital leukemoid reaction
| Autor: | David L. Becton, David R. Head, J. R. Sawyer, G. J. Roloson |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Cancer Research
medicine.medical_specialty Down syndrome Pathology Aneuploidy Bone Marrow Cells Leukemoid Reaction Humans Medicine Acute leukemia business.industry Infant Newborn Cytogenetics Myeloid leukemia Karyotype medicine.disease Leukemia Oncology Leukemia Myeloid Karyotyping Acute Disease Pediatrics Perinatology and Child Health Female Down Syndrome business Leukemoid reaction |
| Zdroj: | Medical and Pediatric Oncology. 22:404-409 |
| ISSN: | 1096-911X 0098-1532 |
| DOI: | 10.1002/mpo.2950220610 |
| Popis: | We report the serial cytogenetic study of a patient with Down syndrome who experienced a congenital leukemoid reaction, underwent a spontaneous remission within four months, and subsequently developed acute myeloid leukemia at 16 months. A blood chromosome study to rule out Down syndrome performed at age 24 days, during the leukemoid reaction, revealed a 47,XX,+21 karyotype. The diagnosis of acute leukemia was made at 16 months, at which time a chromosome study, on bone marrow, was performed. This analysis revealed a clonal karyotype of 47,XX,+21,-22,+der (22)t(1;22)(q21;q13) in all but one cell studied. The single apparently nonclonal cell showed a karyotype of 49,XX,+12,-13,-19, +der(19)t(19;?)(q11;?)x2,+21,+22. A third chromosome study at 19 months indicated the original leukemic clone with t(1;22) (q21;q13) had been replaced by the clone represented by the single cell with 49 chromosomes seen in the previous chromosome study. This case of an infant with Down syndrome and acute leukemia illustrated rapid evolution and a transitory nature to clonal chromosome aberrations while retaining AML morphology and course. © 1994 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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