Gray Matter Decrease of the Anterior Cingulate Cortex in Anorexia Nervosa
| Autor: | Christian Gaser, Bastian Conrad, Peter Lommer, Claus Zimmer, Herbert Backmund, Mark Mühlau, Rüdiger Ilg, Sabine Nunnemann, Monika Gerlinghoff, Afra M. Wohlschläger, Marian H Cebulla, Carl Leibl, Andreas Schnebel |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Cingulate cortex Anorexia Nervosa Adolescent Central nervous system Physiology Grey matter Gyrus Cinguli Severity of Illness Index behavioral disciplines and activities Brain mapping Body Mass Index White matter Sex Factors mental disorders Image Processing Computer-Assisted medicine Humans Age of Onset Anterior cingulate cortex Brain Mapping medicine.diagnostic_test Brain Magnetic resonance imaging Magnetic Resonance Imaging Menstruation Psychiatry and Mental health medicine.anatomical_structure Female Atrophy Psychology Neuroscience Body mass index |
| Zdroj: | American Journal of Psychiatry. 164:1850-1857 |
| ISSN: | 1535-7228 0002-953X |
| DOI: | 10.1176/appi.ajp.2007.06111861 |
| Popis: | The brain regions that are critically involved in the pathophysiology of anorexia nervosa have not been clearly elucidated. Moreover, decrease in cerebral tissue during extreme malnutrition has been demonstrated repeatedly in anorexia nervosa, but data regarding the reversibility of this cerebral tissue decrease are conflicting. The authors examined region-specific gray matter changes and global cerebral volumes in recovered patients with anorexia nervosa.High-resolution, T1-weighted magnetic resonance imaging (MRI) and voxel-based morphometry were performed in 22 recovered women with anorexia nervosa and in 37 healthy comparison women. Recovery was defined as a body mass index above 17.0 kg/m(2) and regular menses for at least 6 months.The global volumes of gray matter (but not white matter) were decreased in patients with anorexia nervosa by approximately 1%. Analyses of region-specific gray matter changes revealed a gray matter decrease bilaterally in the anterior cingulate cortex of approximately 5%, which remained significant after correction for global effects. This gray matter decrease correlated significantly with the lowest body mass index of lifetime but not with other clinical variables.In anorexia nervosa, part of the global gray matter loss persists over the long run. Region-specific gray matter loss in the anterior cingulate cortex is directly related to the severity of anorexia nervosa, indicating an important role of this area in the pathophysiology of the disorder. Further research is warranted to determine the cause, specificity, and functional consequences of this structural brain change in anorexia nervosa. |
| Databáze: | OpenAIRE |
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