SIGLEC15 amplifies immunosuppressive properties of tumor-associated macrophages in pancreatic cancer
| Autor: | Tian-Jiao, Li, Kai-Zhou, Jin, Hao, Li, Long-Yun, Ye, Peng-Cheng, Li, Bruce, Jiang, Xuan, Lin, Zhen-Yu, Liao, Hui-Ru, Zhang, Sai-Meng, Shi, Meng-Xiong, Lin, Qing-Lin, Fei, Zhi-Wen, Xiao, Hua-Xiang, Xu, Liang, Liu, Xian-Jun, Yu, Wei-Ding, Wu |
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| Rok vydání: | 2022 |
| Předmět: |
Immunosuppression Therapy
Cancer Research THP-1 Cells T-Lymphocytes Immunoglobulins Membrane Proteins Gene Expression Regulation Neoplastic Mice Inbred C57BL Pancreatic Neoplasms Mice Oncology Cell Line Tumor Tumor-Associated Macrophages Tumor Microenvironment Animals Cytokines Humans Carcinoma Pancreatic Ductal |
| Zdroj: | Cancer Letters. 530:142-155 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/j.canlet.2022.01.026 |
| Popis: | Pancreatic ductal adenocarcinoma (PDAC) usually presents infrequent infiltration of T lymphocytes. The known immune-checkpoint inhibitors to date focus on activating T cells and manifest limited effectiveness in PDAC. SIGLEC15 was identified as a novel tumor-associated macrophage (TAM)-related immune-checkpoint in other cancer types, while its immunosuppressive role and clinical significance remained unclear in PDAC. In our study, SIGLEC15 presented immunosuppressive relevance in PDAC via bioinformatic analysis and expressed on TAM and PDAC cells. SIGLEC15 |
| Databáze: | OpenAIRE |
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