Patterning and post-patterning modes of evolutionary digit loss in mammals
| Autor: | Margaret M. Brosnahan, Aysu Uygur, Kimberly L. Cooper, Karen E. Sears, D. F. Antczak, Jennifer A. Maier, Julian A. Skidmore, Karl Stephan Baczkowski, Clifford J. Tabin |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Patched Receptors
Camelus Lineage (genetic) Fibroblast Growth Factor 8 Swine Receptors Cell Surface Rodentia Biology Zinc Finger Protein GLI1 Cursorial Article Mice Dipus sagitta biology.animal Animals Hedgehog Proteins Horses Phylogeny Body Patterning Homeodomain Proteins Mammals Oncogene Proteins Multidisciplinary Cell Death Extramural Gene Expression Regulation Developmental Vertebrate Extremities Anatomy Biological evolution biology.organism_classification Biological Evolution Numerical digit Patched-1 Receptor Evolutionary biology Trans-Activators Chondrogenesis |
| Zdroj: | Nature. 511:41-45 |
| ISSN: | 1476-4687 0028-0836 |
| Popis: | A reduction in the number of digits has evolved many times in tetrapods, particularly in cursorial mammals that travel over deserts and plains, yet the underlying developmental mechanisms have remained elusive. Here we show that digit loss can occur both during early limb patterning and at later post-patterning stages of chondrogenesis. In the 'odd-toed' jerboa (Dipus sagitta) and horse and the 'even-toed' camel, extensive cell death sculpts the tissue around the remaining toes. In contrast, digit loss in the pig is orchestrated by earlier limb patterning mechanisms including downregulation of Ptch1 expression but no increase in cell death. Together these data demonstrate remarkable plasticity in the mechanisms of vertebrate limb evolution and shed light on the complexity of morphological convergence, particularly within the artiodactyl lineage. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|