Acute hepatitis B virus infection with simultaneous high HBsAg and high anti-HBs signals in a previously HBV vaccinated HIV-1 positive patient
| Autor: | Laura van Dommelen, H. Rogier van Doorn, Annelies Verbon, Valère J. Goossens |
|---|---|
| Přispěvatelé: | Medische Microbiologie, RS: CARIM School for Cardiovascular Diseases, RS: CAPHRI School for Public Health and Primary Care, Medical Microbiology and Infection Prevention |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male HBsAg Hepatitis B virus HIV Infections medicine.disease_cause Hepatitis Orthohepadnavirus Virology medicine HBV Humans Hepatitis B Vaccines Hepatitis B Antibodies Hepatitis B Surface Antigens biology business.industry Vaccination HIV virus diseases Hepatitis B Viral Load medicine.disease biology.organism_classification digestive system diseases Infectious Diseases Serology Immunology HIV-1 Hepatitis D virus Viral hepatitis business Viral load |
| Zdroj: | Journal of Clinical Virology, 47(3), 293-296. Elsevier Science Journal of clinical virology, 47(3), 293-296. Elsevier |
| ISSN: | 1386-6532 |
| Popis: | We present a case of a clinical manifest hepatitis B virus infection and a potentially misleading HBV serological profile in an HIV-1 positive patient despite previous HBV vaccination. The patient presented with an acute hepatitis B and there was no indication of chronic HBV infection or the presence of a mutation in the 'a' determinant. Remarkably, simultaneously with high HBV surface antigen and HBV viral load, high anti-HBs antibodies were present. If, due to previous HBV vaccination only anti-HBs was tested in this patient, the result of the high anti-HBs antibodies could be very misleading and offering a false sense of security. Our findings contribute to the ongoing discussion on how to assess HBV specific immunological memory and determining the role of HBV booster vaccinations in immunocompromised individuals. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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