Sex differences in symptom severity, cognition and psychosocial functioning among individuals with at‐risk mental state for psychosis
| Autor: | Kit Wa Chan, Wai Ching Yan, Man Wa Siu, Cheuk Fei Wong, San Yin Chiu, Ming Cheuk Wong, Wai Sau Chung, Lai Ming Hui, Pui Fai Pang, Lam Wai Choy, Kwun Nam Chan, Tak Lam Lo, Wing Chung Chang, Eric Y.H. Chen, Lap Tak Poon, Chung Mun Ng, Sai Yu Lui, Shiu Yin Chong, Charles Wai Hong Chan, Wai Chung Lam, Man Kin Ng, Yi Man Mo, Ho Ming Lee, Suet In Chan, Hoi Ching Lee, Y C Wong, Sui Fung Wo, WS Yeung, Kwok Ling Chan |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Psychosis Adolescent Asociality Young Adult 03 medical and health sciences Cognition 0302 clinical medicine Intervention (counseling) medicine Humans Biological Psychiatry Sex Characteristics At risk mental state medicine.disease 030227 psychiatry Cognitive test Psychosocial Functioning Psychiatry and Mental health Psychotic Disorders Schizophrenia Female Pshychiatric Mental Health Psychology Psychosocial 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Early Intervention in Psychiatry. 16:61-68 |
| ISSN: | 1751-7893 1751-7885 |
| DOI: | 10.1111/eip.13131 |
| Popis: | Aim Sex differences are well documented in schizophrenia, but have been much less studied in at-risk mental state (ARMS) for psychosis. We aimed to examine sex differences in symptomatology, cognition, social and role functioning in individuals with ARMS, with specific focus on clarifying relationships between sex, negative symptoms and functioning. Methods One hundred and seventy-seven Chinese participants aged 15-40 years with ARMS were recruited from a specialized early intervention service in Hong Kong. ARMS status was verified by Comprehensive Assessment of At-Risk Mental State. Assessments encompassing symptom profiles, a brief battery of cognitive tests and social and role functioning were conducted. Brief Negative Symptom Scale was adapted to measure negative symptoms at the level of five core domains. Results Males with ARMS exhibited significantly poorer social functioning and more severe asociality of negative symptoms than female counterparts. Mediation analysis revealed that sex difference in social functioning became statistically insignificant when asocality was included in the model, indicating that asociality mediated the relationship between sex and social functioning. No sex differences were observed in other core domains of negative symptoms, other symptom dimensions, cognitive measures and role functioning. Conclusions This study suggests that sex differences in ARMS may be less pronounced that those observed in established psychotic disorders. Our findings of differential pattern of asociality between sexes and its mediating role on sex difference in social functioning underscore the importance in investigating negative symptoms at a separable domain-level. Further research is required to identify sex-specific predictors of longitudinal outcomes in at-risk populations. |
| Databáze: | OpenAIRE |
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