Peptide selection for presentation by HLA class I: A role for the human transporter associated with antigen processing?
| Autor: | van Endert Pm |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Genetics
chemistry.chemical_classification Antigen Presentation biology Antigen processing Histocompatibility Antigens Class I Immunology Antigen presentation Transporter Peptide Transporter associated with antigen processing Human leukocyte antigen Computational biology Epitope chemistry HLA Antigens MHC class I biology.protein Humans ATP-Binding Cassette Transporters Peptides |
| Zdroj: | Immunologic Research. 15:265-279 |
| ISSN: | 1559-0755 0257-277X |
| DOI: | 10.1007/bf02935312 |
| Popis: | Peptide epitopes presented by HLA class I are supplied by an elaborate system of antigen processing which subjects candidate epitopes to a process of selection according to little-understood rules. Transport of peptides from the cytosol into the endoplasmic reticulum by the TAP (transporter associated with antigen processing) complex is likely to play an important role in peptide selection for presentation. The recent development of an assay measuring substrate binding to the TAP complex has led to the identification of the major structural properties of peptides selected by the human transporter. Human TAP favors transport of peptides with structural features common to HLA class I ligands. However, TAP dislikes peptide ligands preferred by some HLA class I alleles, which may therefore frequently rely on alternative sources of peptide ligands. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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