Safety and Efficiency of Transplantation of Allogenic Multipotent Stromal Cells in Surgical Treatment of Dilatated Cardiomyopathy
| Autor: | A. V. D’yachkov, N. P. Bochkov, D. V. Goldstein, T. Kh. Fatkhutdinov, A. V. Koroteyev |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Cardiomyopathy Dilated Male medicine.medical_specialty Stromal cell Chronic cardiac failure medicine.drug_class Cardiomyopathy Statistics Nonparametric General Biochemistry Genetics and Molecular Biology Natriuretic Peptide Brain medicine Natriuretic peptide Humans Transplantation Homologous Stage (cooking) Surgical treatment Aged Bone Marrow Transplantation Heart Failure business.industry Multipotent Stem Cells General Medicine Middle Aged medicine.disease Brain natriuretic peptide Surgery Transplantation Treatment Outcome Stromal Cells business |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 149:119-124 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | Clinical study of intracoronary transplantation of allogenic multipotent bone marrow stromal cells was carried out in patients with severe chronic cardiac failure against the background of dilatated cardiomyopathy. The results indicate that intracoronary injection of allogenic multipotent stromal precursors is a safe procedure. No complications and side effects directly or indirectly related to cell transplantation were recorded during the immediate and delayed postoperative periods. The positive effect of cell transplantation developed from week 1 after transplantation and persisted for 6 months. It manifested in reduction of the level of brain natriuretic peptide and improvement of patient's functional status and quality of life. No appreciable changes in the main echocardiographic values were noted. Transplantation of allogenic multipotent stromal cells is effective as a component of combined therapy for chronic cardiac failure at the stage of preparation to surgery as a "bridge to surgical treatment". |
| Databáze: | OpenAIRE |
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