Beta-Adrenergic Blockade Decreases the Neuroimmune Changes in Mice Induced by Cohabitation with an Ehrlich Tumor-Bearing Cage Mate
| Autor: | Rafael Oliveira Margatho, Cristina de Oliveira Massoco, Jorge Camilo Flório, Glaucie Jussilane Alves, Atilio Sersun Calefi, D.S.G. Cruz, Thaísa Meira Sandini, João Palermo-Neto |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Sympathetic nervous system RECEPTORES ADRENÉRGICOS Phagocytosis Immunology Mice 03 medical and health sciences Norepinephrine Adrenergic Agents Catecholamines 0302 clinical medicine Endocrinology Neurochemical Internal medicine Adrenal Glands medicine Animals Interpersonal Relations Carcinoma Ehrlich Tumor Illness Behavior Endocrine and Autonomic Systems Chemistry Flow Cytometry Blockade Disease Models Animal 030104 developmental biology medicine.anatomical_structure Neurology Exploratory Behavior Catecholamine Female Serotonin Corticosterone 030217 neurology & neurosurgery Hormone medicine.drug |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1423-0216 1021-7401 |
| DOI: | 10.1159/000477938 |
| Popis: | Objectives: Cohabitation with Ehrlich tumor-bearing (ETB) mice induced behavioral, neurochemical, hormonal, and immune effects in the conspecifics as a consequence of stress-induced activation of the sympathetic nervous system (SNS) with catecholamine release. In the current study, the nonspecific β-AR blocker d,l-propranolol and the specific β2-AR blocker ICI-118.551 were employed as pharmacological tools to assess the extent to which catecholamines participated in the effects induced by cohabitation with ETB mice. Methods: Two experiments were performed, 1 with d,l-propranolol treatment and the other with ICI-118.551. One mouse in the experimental group was called the “companion of the sick partner” (CSP) since it was forced to live in the same cage with 2 (experiment 1) or 1 (experiment 2) cage mate that had been i.p. injected with 5 × 106 Ehrlich tumor cells. Results: The d,l-propranolol treatment, but not the ICI-118.551 treatment, attenuated the effects of cohabitation with 2 ETB mice on both open-field behavior and the hypothalamic levels and turnover rate of norepinephrine. The 2 β-AR blockers were unable to change the serum corticosterone levels and adrenal weights of the CSP mice; however, these drugs abrogated the effects of cohabitation on neutrophil oxidative burst and phagocytosis. Finally, an increase in the 5-HT turnover rate was observed in the olfactory bulb of CSP mice compared to their respective controls, an effect that was not modified by β-AR blockade. Conclusion: These results confirm and strengthen our hypothesis that the SNS is involved in the effects induced by cohabitation with ETB mice and point towards β2-AR participation in the immune effects analyzed. |
| Databáze: | OpenAIRE |
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