Long-term results of the treatment of Hodgkin’s lymphoma in a resource-constrained setting: Real-world data from a single center
| Autor: | Iván Murrieta-Álvarez, Juan Carlos Olivares-Gazca, Guillermo J. Ruiz-Argüelles, Andrés A. León-Peña, Yahveth Cantero-Fortiz, Montserrat Rivera-Álvarez, Alejandra Carmina Córdova-Ramírez, Luisa Fernanda Sánchez-Valledor, Thomas M. Habermann, Guillermo J. Ruiz-Delgado |
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| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty Lymphoma business.industry Resource constrained Long term results Hodgkin's lymphoma medicine.disease Single Center Treatment Hodgkin Oncology immune system diseases hemic and lymphatic diseases medicine Retrospective Cohort Study ABVD chemotherapy business Real world data |
| Zdroj: | World Journal of Clinical Oncology |
| ISSN: | 2218-4333 |
| Popis: | BACKGROUND The outcomes of Hodgkin´s lymphoma (HL) in México have not been widely reported. Simplified and affordable treatments have been adopted in middle-income countries. AIM The aim was to evaluate long-used therapies for HL in México in a long-term basis. METHODS In a 34-year time period, 88 patients with HL were treated at a single institution in México. Patients were treated with adriamycin bleomycin vinblastine and dacarbazine (ABVD) or mechlorethamine, vincristine, procarbazine, and prednisone (MOPP). Relapsed or refractory patients were given ifosfamide, carboplatin, and etoposide (ICE) followed by autologous or allogeneic stem cell transplants. RESULTS Thirty-seven women and 51 men were included; the median age was 29 years. Patients were followed for a mean of 128 mo. The 310-mo overall survival (OS) was 83% for patients treated with MOPP and 88% for those treated with ABVD. The OS of patients who received autologous stem cell transplantation was 76% (330 mo) vs 93% (402 mo) in those who did not. CONCLUSION HL may be less aggressive in Mexican population than in Caucasians. Combined chemotherapy renders acceptable results, regardless of clinical stage. |
| Databáze: | OpenAIRE |
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