Increased Protein Tyrosine Kinase Activity of the Colonic Mucosa in Ulcerative Colitis
| Autor: | Horai T, Y. Sakanoue, Joji Utsunomiya, Masato Kusunoki, T Okamoto, Takuya Hatada |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty animal structures Adolescent Colorectal cancer Immunocytochemistry Inflammation Gastroenterology Cytosol Internal medicine medicine Humans Intestinal Mucosa Colitis Aged chemistry.chemical_classification business.industry Middle Aged Protein-Tyrosine Kinases medicine.disease Ulcerative colitis digestive system diseases Colonic mucosa Enzyme chemistry Colitis Ulcerative Female medicine.symptom business Tyrosine kinase |
| Zdroj: | Scandinavian Journal of Gastroenterology. 27:686-690 |
| ISSN: | 1502-7708 0036-5521 |
| DOI: | 10.3109/00365529209000140 |
| Popis: | The protein tyrosine kinase (PTK) activity was measured in the inflamed colonic mucosa of 12 patients with ulcerative colitis and in the normal colonic mucosa of 12 control patients with colon cancer. The specific PTK activity in the particulate fraction obtained from ulcerative colitis mucosa was significantly increased compared with that of normal mucosa (5.10 +/- 0.60 pmol/min/mg versus 2.12 +/- 0.44 pmol/min/mg protein; p less than 0.05). Inflamed ulcerative colitis mucosa also showed a significantly higher total PTK activity in the particulate fraction than normal mucosa (2.60 +/- 0.42 pmol/min/g versus 0.91 +/- 0.16 pmol/min/g tissue; p less than 0.05). Mucosal samples from ulcerative colitis patients were divided into those with mild and those with severe inflammation on histologic examination (n = 6 each). The particulate PTK activity of severely inflamed mucosa was significantly higher than that of mildly inflamed mucosa (p less than 0.05). These results suggest that colonic inflammation in ulcerative colitis is associated with alterations in cellular PTK activity. |
| Databáze: | OpenAIRE |
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