Possible failure of novel direct-acting oral anticoagulants in management of pulmonary embolism: a case report
| Autor: | Richard J. Pietras, Uri M. Ben-Zur, Nojan Toomari, James Rankin, Jonathan Crosby, Menachem Nagar |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Oral
Adult medicine.medical_specialty Chest Pain Vitamin K medicine.drug_mechanism_of_action Factor Xa Inhibitor Embolism Administration Oral Factor Xa inhibitor Case Report 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine General & Internal Medicine Case report medicine Pleuritic chest pain Humans cardiovascular diseases 030212 general & internal medicine Treatment Failure Intensive care medicine Lung Anticoagulant therapy Nutrition Medicine(all) Other Medical and Health Sciences business.industry Prevention Warfarin Angiography Anticoagulants Thrombosis Hematology General Medicine medicine.disease Pulmonary embolism Safety profile Dyspnea Administration Female business Pulmonary Embolism Direct acting medicine.drug |
| Zdroj: | Journal of medical case reports, vol 10, iss 1 Journal of Medical Case Reports |
| ISSN: | 1752-1947 |
| DOI: | 10.1186/s13256-016-1135-9 |
| Popis: | Background The relative effectiveness of vitamin K antagonists compared with novel oral anticoagulants in treating pulmonary embolism remains unclear. Recent trials comparing the efficacy of vitamin K antagonists with factor Xa inhibitors for the treatment of pulmonary emboli have been non-inferiority studies based primarily on risk reduction (such as bleeding events), rather than resolution of specific diseases such as pulmonary embolism. Consequently, there is a lack of evidence indicating which of these agents are more effective. Here, we present a case where pulmonary emboli were treated with novel oral anticoagulants followed by warfarin to discuss the potential limitations in the use of novel oral anticoagulants as prevention or treatment of thromboembolism and the continued role for warfarin in this setting. Case presentation A 34-year-old African American woman presented to our clinic with shortness of breath and pleuritic chest pain several months post-surgery. She was identified as having multiple bilateral pulmonary embolisms and was treated with several novel oral anticoagulants, which failed to resolve the clots. Complete resolution was achieved upon switching to warfarin. Conclusions The patient described in this report failed to respond to novel oral anticoagulant therapy, but her emboli resolved when she was treated with warfarin. This study challenges the notion that factor Xa inhibitors are better alternatives to vitamin K anticoagulants in the treatment of pulmonary emboli based on their safety profile and ease of use alone. As a result, further post-marketing investigations into the efficacy of these agents in the management of pulmonary emboli may be warranted. |
| Databáze: | OpenAIRE |
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