A Eu(III)-based Metal Organic Framework: Selective Sensing of Picric Acid and Nursing Application Values On the Cerebral Edema Induced by Cerebral Hemorrhage Via Reducing the Coagulation Factor II Activity
| Autor: | Xiao-Chang Chen, Rong Liu, Feng Xi, Jia-Wen Zhou |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Lanthanide
Models Molecular Sociology and Political Science Clinical Biochemistry Picric acid Brain Edema Enzyme-Linked Immunosorbent Assay 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry Cerebral edema Ion Rats Sprague-Dawley chemistry.chemical_compound Europium Picrates Coordination Complexes medicine Animals Spectroscopy Metal-Organic Frameworks Cerebral Hemorrhage Quenching (fluorescence) 010405 organic chemistry medicine.disease 0104 chemical sciences Rats Clinical Psychology chemistry Metal-organic framework Prothrombin Luminescence Law Oxidation-Reduction Social Sciences (miscellaneous) Coagulation Factor II |
| Zdroj: | Journal of fluorescence. 31(2) |
| ISSN: | 1573-4994 |
| Popis: | A new three-dimensional lanthanide metal–organic framework (Ln-MOF), [Eu4(L)4(H2O)8]·10H2O (1, H3L = biphenyl-3′-nitro-3,4′,5-tricarboxylic acid), has been constructed via solvothermal technology and its framework has been detected by the single-crystal X-ray diffraction and elemental analyses. Complex 1 with typical emission of Eu3+ ion represents dramatic luminescence quenching affect for picric acid (PA) and the linear Stern-Volmer plot was surveyed in the consistence, ranging from 0.05 to 0.15 mM (Ksv = 98,074 M− 1). Its therapeutic effect of the compound on the cerebral edema caused by cerebral hemorrhage was estimated and the mechanism was explored. Possible binding interactions have been investigated by molecular docking simulations, from which the binding interactions are identified and the carboxyl oxygens are responsible for those identified interactions. |
| Databáze: | OpenAIRE |
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