Radiation Biology and Its Role in the Canadian Radiation Protection Framework
| Autor: | Julie Burtt, Julie Leblanc |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Radiobiology
Neoplasms Radiation-Induced Epidemiology Computer science Health Toxicology and Mutagenesis Radiation Dosage Risk Assessment 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Radiation Protection High doses Humans Radiology Nuclear Medicine and imaging business.industry Radiation dose Low dose Radiation Exposure Radiation exposure Risk analysis (engineering) 030220 oncology & carcinogenesis Radiation protection business Risk assessment Cancer risk |
| Zdroj: | Health physics. 117(3) |
| ISSN: | 1538-5159 |
| Popis: | The linear no-threshold (linear-non-threshold) model is a dose-response model that has long served as the foundation of the international radiation protection framework, which includes the Canadian regulatory framework. Its purpose is to inform the choice of appropriate dose limits and subsequent as low as reasonably achievable requirements, social and economic factors taken into account. The linear no-threshold model assumes that the risk of developing cancer increases proportionately with increasing radiation dose. The linear no-threshold model has historically been applied by extrapolating the risk of cancer at high doses (>1,000 mSv) down to low doses in a linear manner. As the health effects of radiation exposure at low doses remain ambiguous, reducing uncertainties found in cancer risk dose-response models can be achieved through in vitro and animal-based studies. The purpose of this critical review is to analyze whether the linear no-threshold model is still applicable for use by modern nuclear regulators for radiation protection purposes, or if there is sufficient scientific evidence supporting an alternate model from which to derive regulatory dose limits. |
| Databáze: | OpenAIRE |
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