Asymmetric Synthesis of Piperidines and Octahydroindolizines

Autor:	Stephen G. Davies, Angela J. Russell, Deri G. Hughes, Paul M. Roberts, Andrew Smith, James E. Thomson, Paul D. Price, Oliver Williams
Jazyk:	angličtina
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Lithium amide chemistry Bicyclic molecule Coniine Hydrochloride Stereochemistry Organic Chemistry Enantioselective synthesis Conjugate
Zdroj:	SYNLETT. 2010(4)
ISSN:	1437-2096 0936-5214
Popis:	The conjugate addition of a homochiral lithium amide to a ξ-hydroxy-α,β-unsaturated ester, followed by a one-pot, ring-closure-N-debenzylation protocol has been used in the asymmetric syntheses of (S)-coniine and (R)-δ-coniceine (isolated as the corresponding hydrochloride salts) and the bicyclic core of stellettamide A. © Georg Thieme Verlag Stuttgart.
Databáze:	OpenAIRE
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