Coulter Counter measurements of solubility and dissolution rate of sparingly soluble compounds using micellar solutions

Autor:	Christer Nyström, M Bisrat
Rok vydání:	1986
Předmět:	Pharmacology Chromatography Felodipine Nifedipine Surface Properties Chemistry Inorganic chemistry Pharmaceutical Science Micelle Griseofulvin Dosage form Molar solubility Kinetics Solubility Pulmonary surfactant Coulter counter Micellar solutions Particle Size Dissolution Micelles
Zdroj:	Journal of Pharmacy and Pharmacology. 38:420-425
ISSN:	2042-7158 0022-3573
DOI:	10.1111/j.2042-7158.1986.tb04604.x
Popis:	A Coulter Counter, Model TAII, was used to determine both solubility and surface specific dissolution rate of two sparingly soluble materials suspended in micellar solutions. The equilibrium solubility increased linearly with surfactant concentration, thereby making it possible by extrapolation to characterize materials with an aqueous solubility down to 1 ppm or less. At high concentrations (>0.1% w/v) the effect of surfactant concentration on the surface specific dissolution rate was less than that predicted from the increased bulk solubility.
Databáze:	OpenAIRE
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