A simple, one pot synthesis of furo[3,2- c ]chromenes and evaluation of antimicrobial activity
| Autor: | C. Ganesh Kumar, Krishnaiah Atmakur, Ashok Kale, Chiranjeevi Bingi, Sarada Sripada |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Klebsiella
Clinical Biochemistry Pharmaceutical Science Microbial Sensitivity Tests Bacillus subtilis Gram-Positive Bacteria 010402 general chemistry medicine.disease_cause 01 natural sciences Biochemistry Microbiology Structure-Activity Relationship Anti-Infective Agents Candida albicans Gram-Negative Bacteria Drug Discovery medicine Benzopyrans Molecular Biology Escherichia coli biology 010405 organic chemistry Chemistry fungi Organic Chemistry Antimicrobial biology.organism_classification 0104 chemical sciences Ciprofloxacin Staphylococcus aureus bacteria Molecular Medicine Micrococcus luteus medicine.drug Nuclear chemistry |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 26:4899-4902 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2016.09.022 |
| Popis: | Synthesis of a number of 2-cyano-4-oxo-3-phenyl-3,4-dihydro-2H-furo[3,2-c]chromene-2-carboxylate compounds (5) have been accomplished by a simple, multicomponent one pot reaction and evaluated for in vitro antimicrobial activity against different Gram-positive and Gram-negative bacterial strains. The outcome of the screening study showed that compound 5c exhibited promising activity against Micrococcus luteus MTCC 2470 and Klebsiella planticola MTCC 530. Whereas, compound 5g exhibited excellent activity against Bacillus subtilis MTCC 121, Micrococcus luteus MTCC 2470, Klebsiella planticola MTCC 530, Escherichia coli MTCC 739 and displayed a moderate activity against Staphylococcus aureus MTCC 96 and Candida albicans MTCC 3017 when compared with Ciprofloxacin (standard control). |
| Databáze: | OpenAIRE |
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