Formate Dehydrogenases Reduce CO 2 Rather than HCO 3 − : An Electrochemical Demonstration
| Autor: | Marta Meneghello, Inês A. C. Pereira, Ana Rita Oliveira, Vincent Fourmond, Christophe Léger, Aurore Jacq-Bailly |
|---|---|
| Přispěvatelé: | Bioénergétique et Ingénierie des Protéines (BIP ), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), ANR-14-CE05-0010,HEROS,Hydrogénases résistantes à l'Oxygène(2014), ANR-15-CE05-0020,shields,Des films de polymères pour supporter et protéger des catalyseurs d'oxydation de l'hydrogène et de réduction du CO2(2015), ANR-17-CE11-0027,MeCO2Bio,Études mécanistiques de la réduction du CO2: exploration de la biodiversité des CO déshydrogénases(2017), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU) |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
[SDV]Life Sciences [q-bio] education Inorganic chemistry [CHIM.INOR]Chemical Sciences/Inorganic chemistry Formate dehydrogenase 010402 general chemistry Electrochemistry bioelectrochemistry carbonic anhydrase Formate dehydrogenase CO dehydrogenase CO2 reduction protein film voltammetry 01 natural sciences Catalysis 03 medical and health sciences chemistry.chemical_compound medicine [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Formate 030304 developmental biology 0303 health sciences 010405 organic chemistry Substrate (chemistry) General Chemistry General Medicine Combinatorial chemistry 0104 chemical sciences CO dehydrogenase chemistry Bioelectrochemistry Protein film voltammetry |
| Zdroj: | Angewandte Chemie International Edition Angewandte Chemie International Edition, 2021, ⟨10.1002/anie.202101167⟩ Angewandte Chemie International Edition, Wiley-VCH Verlag, 2021, ⟨10.1002/anie.202101167⟩ Angew Chem Int |
| ISSN: | 1521-3757 0044-8249 1433-7851 1521-3773 |
| DOI: | 10.1002/ange.202101167 |
| Popis: | International audience; Mo/W formate dehydrogenases catalyze the reversible reduction of CO 2 species to formate. It is thought that the substrate is CO 2 and not a hydrated species like HCO-3 , but there is still no indisputable evidence for this, in spite of the extreme importance of the nature of the substrate for mechanistic studies. We devised a simple electrochemical method to definitely demonstrate that the substrate of formate dehydrogenases is indeed CO 2 . |
| Databáze: | OpenAIRE |
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