The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. II. Structure elucidation
| Autor: | Nigel Stephen Stevenage Watson, Rona M. Highcock, Philip J. Sidebottom, Lane Stephen Joseph, Pan A. Procopiou |
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| Rok vydání: | 1992 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Farnesyl-diphosphate farnesyltransferase Antifungal Agents biology Bicyclic molecule Stereochemistry Farnesyltransferase Tricarboxylic Acids Zaragozic acid biology.organism_classification Bridged Bicyclo Compounds Heterocyclic chemistry.chemical_compound Squalene Bridged Bicyclo Compounds Structure-Activity Relationship Enzyme Farnesyl-Diphosphate Farnesyltransferase chemistry Biochemistry Drug Discovery Phoma biology.protein Structure–activity relationship |
| Zdroj: | The Journal of antibiotics. 45(5) |
| ISSN: | 0021-8820 |
| Popis: | Three novel fungal metabolites 1-3 isolated from cultures of a Phoma sp. C2932, are potent and selective inhibitors of squalene synthase. Their structures have been determined by a combination of spectroscopic, X-ray crystallographic and chemical methods; these natural products incorporate the highly functionalised bicyclic core, [1S-(1 alpha, 3 alpha, 4 beta, 5 alpha, 6 alpha, 7 beta]-4,6,7-trihydroxy- 2,8-dioxabicyclo-[3.2.1]octane-3,4,5-tricarboxylic acid. |
| Databáze: | OpenAIRE |
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