Clinical significance of risk stratification of esophageal squamous cell carcinoma after neoadjuvant chemoradiation and surgery
| Autor: | Ming-qiang Lin, Jian-cheng Li, Yahua Wu, Zhiping Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty DFS disease-free survival 3DRT three-dimensional conformal radiation therapy Adjuvant chemotherapy GTV gross tumor volume medicine.medical_treatment Locally advanced Adujvant treatment NCRT neoadjuvant chemoradiation Esophageal squamous cell carcinoma lcsh:RC254-282 OS overall survival 03 medical and health sciences 0302 clinical medicine KPS Karnofsky Performance Status Recurrence medicine Clinical significance CTV clinical target volume Pathological Risk stratification Original Research 2DRT two-dimensional conformal radiation therapy business.industry LVI lymph vessel invasion IMRT intensity-modulated radiation therapy lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens HR hazard ratio pCR pathological complete respond Neoadjuvant chemoradiation Surgery CI confidence interval 030104 developmental biology Oncology Esophagectomy 030220 oncology & carcinogenesis LN lymph node ESCC esophageal squamous cell carcinoma PNI perineural invasion business PTV planning target volume Adjuvant |
| Zdroj: | Translational Oncology, Vol 14, Iss 5, Pp 101037-(2021) Translational Oncology |
| ISSN: | 1936-5233 |
| Popis: | Highlight • Neoadjuvant chemoradiation (NCRT) followed by surgery was regarded as the standard treatment of locally advanced esophageal cancer. However, studies have reported that almost 31%−50% of esophageal cancer patients still have local recurrence and or distant metastasis after NCRT and surgery. At present, there are few reports on the risk stratification of patients with esophageal carcinoma after NCRT and surgery. The valuable effect of adjuvant chemotherapy in esophageal squamous cell carcinoma (ESCC) patients underwent NCRT followed by surgery remains controversial. There is also no consensus that whether patients need adjuvant chemotherapy. Reasonable risk stratification is therefore required that helps postoperatively surveillance and classify patients suitable for adjuvant chemotherapy. There remains, however, no reliable forecasting system for ESCC patients after NCRT and surgery. Based on the current status, we carry out a noval risk stratification to predict survival, recurrence and classify patients at high risk that may benefit from adjuvant therapy according to clinicophological factors Objective Nowadays, there were few studies reporting the risk stratification of patients with esophageal squamous cell carcinoma (ESCC) after neoadjuvant chemoradiation (NCRT) and surgery. We aimed to establish a simple risk stratification to help postoperative detection and adjuvant treatment. Methods We included 146 patients with locally advanced ESCC who received NCRT followed by esophagectomy. The impacts of clinicopathological factors on overall survival (OS) and disease-free survival (DFS) were analyzed. The recurrence site, time, and frequency were recorded as well. Results The median follow-up was 53 months. The pathological complete respond (pCR) group demonstrated better 5-year OS and DFS (78.6% and 77.0%) than the non-pCR group (44.8% and 35.2%, all P |
| Databáze: | OpenAIRE |
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