Monoclonal antibodies to the major structural proteins of bacteriophage phi 6
| Autor: | Päivi M. Pekkala, Dennis H. Bamford, Vesa M. Olkkonen |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Viral Structural Proteins
biology medicine.drug_class viruses Bacteriophage phi 6 Antibodies Monoclonal biology.organism_classification Monoclonal antibody Antibodies Viral Molecular biology Cystovirus Virus Bacteriophage Viral Proteins Capsid Immunoglobulin M Antibody Specificity Virology Immunoglobulin G biology.protein medicine Bacteriophages Antibody Receptor Polymerase |
| Zdroj: | Virology. 165(1) |
| ISSN: | 0042-6822 |
| Popis: | A panel of 38 monoclonal antibodies to the five major structural proteins of φ6 was generated and characterized. The panel includes antibodies recognizing the receptor recognition protein P3, the major hydrophobic envelope protein P9, the nucleocapsid surface protein P8, and the nucleocapsid proteins P1 and P4, which are involved in the viral RNA polymerase activity and form the internal protein skeleton of the nucleocapsid. Six out of the fourteen antibodies to the receptor recognition protein, P3, showed neutralizing activity, interfering with the adsorption of φ6 to host cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|