High-Frequency Ultrasound Assessment of Skin and Oral Mucosa in Metabolic Syndrome Patients—A Cross-Sectional Study

Autor:	Maria Crișan, Artur Bezugly, Cristian Dinu, Claudia Nicoleta Feurdean, Radu Septimiu Câmpian, Anca Ionel, Bianca Adina Boșca, Mihaela Băciuț, Bogdan Crișan, Aranka Ilea, Anida Maria Băbțan, Ioana Roxana Bordea, Carmen Mihaela Mihu, Ștefan Cristian Vesa
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Pathology medicine.medical_specialty skin Cutis Article metabolic syndrome Dermis Medicine Oral mucosa integumentary system oral mucosa business.industry Ultrasound aging Soft tissue General Medicine high-frequency ultrasound medicine.disease medicine.anatomical_structure inflammation Epidermis Metabolic syndrome business Subcutaneous tissue
Zdroj:	Journal of Clinical Medicine Volume 10 Issue 19 Journal of Clinical Medicine, Vol 10, Iss 4461, p 4461 (2021)
ISSN:	2077-0383
DOI:	10.3390/jcm10194461
Popis:	Background: Exogenous factors (such as sun exposure, smoking habits, and diet) and endogenous (inflammatory status, general diseases) have a direct influence on skin and soft tissue characteristics. The study’s objective was to assess the impact of metabolic syndrome (MS) on characteristics of skin layers in sun-exposed and non-exposed maxillofacial tissues evaluated by high-frequency ultrasound (HFU), as a potential diagnosis and monitoring tool for the aging process. Material and methods: The present study included 102 subjects (24 with MS 78 without MS). Anthropometric parameters and disease history were recorded, and blood samples were harvested in order to assess biochemical parameters of MS. Sun-exposed skin (zygomatic region) and non-exposed oral mucosa of the lower lip were assessed using HFU (DUB® cutis, Taberna Pro Medicum) with a 22 MHz probe. Results: Patients with cardiac disease had significantly lower values for epidermis density (p = 0.002). Gender was independently linked to the aged dermis depth (p < 0.001), aged dermis no. of px (pixels) (p < 0.001), dermis depth (p < 0.001), dermis no. of px (p < 0.001), and subcutaneous tissue density (p < 0.001). Patients with MS had thinner epidermis (p = 0.008) and thinner aged dermis (p = 0.037) when compared to non-MS subjects. Conclusion: Patients with MS had thinner epidermis and a lower epidermis number of pixels in sun-exposed skin. Women had lower epidermis density and thicker dermis in sun-exposed skin. Our study showed that HFU, as a non-invasive investigation approach, is useful to diagnose and monitor the aging process in skin and oral mucosa, correlated with skin phenotype pathological conditions.
Databáze:	OpenAIRE
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