High MMP-11 expression associated with low CD8+ T cells decreases the survival rate in patients with breast cancer
Autor: | Hyung Suk Kim, Min Gyu Kim, Dong-Hoon Kim, Kyueng-Whan Min, Un Suk Jung |
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Rok vydání: | 2021 |
Předmět: |
Receptor
ErbB-2 Cancer Treatment Aminopyridines CD8-Positive T-Lymphocytes Metastasis White Blood Cells Animal Cells Breast Tumors Testicular Cancer Medicine and Health Sciences Genitourinary Cancers Tumor Microenvironment Cytotoxic T cell Immune Response Sulfonamides Multidisciplinary T Cells Liver Diseases Middle Aged Gene Expression Regulation Neoplastic Survival Rate medicine.anatomical_structure Oncology MCF-7 Cells Medicine Cancer/testis antigens Female Cellular Types Research Article Indazoles Science Immune Cells Urology T cell Immunology Cytotoxic T cells Breast Neoplasms Gastroenterology and Hepatology Lymphocytes Tumor-Infiltrating Breast cancer Matrix Metalloproteinase 11 Breast Cancer Gastrointestinal Tumors medicine Humans Colorectal Cancer Blood Cells Tumor-infiltrating lymphocytes business.industry Carcinoma Cancers and Neoplasms Biology and Life Sciences Cancer Cell Biology Hepatocellular Carcinoma medicine.disease Survival Analysis Genitourinary Tract Tumors Cancer research Pyrazoles business Memory T cell |
Zdroj: | PLoS ONE PLoS ONE, Vol 16, Iss 5, p e0252052 (2021) |
ISSN: | 1932-6203 |
Popis: | Matrix metalloproteinase-11 (MMP-11) promote cancer invasion and metastasis through degrading the extracellular matrix. Protein degradation by MMP-11 in tumor cells may progressively suppress cancer surveillance activities with blocking immune response in breast cancer. The aim of study is to analyze clinicopathological parameters, molecular interactions and anticancer immune response in patients with MMP-11 expression and to provide candidate target drugs. We investigated the clinicopathologic parameters, specific gene sets, tumor antigenicity, and immunologic relevance according to MMP-11 expression in 226 and 776 breast cancer patients from the Hanyang University Guri Hospital (HUGH) cohort and The Cancer Genome Atlas (TCGA) data, respectively. We analyzed pathway networks and in vitro drug response. High MMP-11 expression was associated with worse survival rate in breast cancer from HUGH cohort and TCGA data (all p < 0.05). In analysis of immunologic gene sets, high MMP-11 expression was related to low immune response such as CD8+T cell, CD4+T cell and B cell. In silico cytometry, there was a decrease of cancer testis antigen and low tumor infiltrating lymphocyte in patient with high MMP-11 expression: activated dendritic cell, CD8+T cell, CD4+ memory T cell, and memory B cell. In pathway networks, MMP-11 was linked to the pathways including low immune response, response to growth hormone and catabolic process. We found that pictilisib and AZ960 effectively inhibited the breast cancer cell lines with high MMP-11 expression. Strategies making use of MMP-11-related hub genes could contribute to better clinical management/research for patients with breast cancer. |
Databáze: | OpenAIRE |
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