High MMP-11 expression associated with low CD8+ T cells decreases the survival rate in patients with breast cancer

Autor: Hyung Suk Kim, Min Gyu Kim, Dong-Hoon Kim, Kyueng-Whan Min, Un Suk Jung
Rok vydání: 2021
Předmět:
Receptor
ErbB-2
Cancer Treatment
Aminopyridines
CD8-Positive T-Lymphocytes
Metastasis
White Blood Cells
Animal Cells
Breast Tumors
Testicular Cancer
Medicine and Health Sciences
Genitourinary Cancers
Tumor Microenvironment
Cytotoxic T cell
Immune Response
Sulfonamides
Multidisciplinary
T Cells
Liver Diseases
Middle Aged
Gene Expression Regulation
Neoplastic
Survival Rate
medicine.anatomical_structure
Oncology
MCF-7 Cells
Medicine
Cancer/testis antigens
Female
Cellular Types
Research Article
Indazoles
Science
Immune Cells
Urology
T cell
Immunology
Cytotoxic T cells
Breast Neoplasms
Gastroenterology and Hepatology
Lymphocytes
Tumor-Infiltrating
Breast cancer
Matrix Metalloproteinase 11
Breast Cancer
Gastrointestinal Tumors
medicine
Humans
Colorectal Cancer
Blood Cells
Tumor-infiltrating lymphocytes
business.industry
Carcinoma
Cancers and Neoplasms
Biology and Life Sciences
Cancer
Cell Biology
Hepatocellular Carcinoma
medicine.disease
Survival Analysis
Genitourinary Tract Tumors
Cancer research
Pyrazoles
business
Memory T cell
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 5, p e0252052 (2021)
ISSN: 1932-6203
Popis: Matrix metalloproteinase-11 (MMP-11) promote cancer invasion and metastasis through degrading the extracellular matrix. Protein degradation by MMP-11 in tumor cells may progressively suppress cancer surveillance activities with blocking immune response in breast cancer. The aim of study is to analyze clinicopathological parameters, molecular interactions and anticancer immune response in patients with MMP-11 expression and to provide candidate target drugs. We investigated the clinicopathologic parameters, specific gene sets, tumor antigenicity, and immunologic relevance according to MMP-11 expression in 226 and 776 breast cancer patients from the Hanyang University Guri Hospital (HUGH) cohort and The Cancer Genome Atlas (TCGA) data, respectively. We analyzed pathway networks and in vitro drug response. High MMP-11 expression was associated with worse survival rate in breast cancer from HUGH cohort and TCGA data (all p < 0.05). In analysis of immunologic gene sets, high MMP-11 expression was related to low immune response such as CD8+T cell, CD4+T cell and B cell. In silico cytometry, there was a decrease of cancer testis antigen and low tumor infiltrating lymphocyte in patient with high MMP-11 expression: activated dendritic cell, CD8+T cell, CD4+ memory T cell, and memory B cell. In pathway networks, MMP-11 was linked to the pathways including low immune response, response to growth hormone and catabolic process. We found that pictilisib and AZ960 effectively inhibited the breast cancer cell lines with high MMP-11 expression. Strategies making use of MMP-11-related hub genes could contribute to better clinical management/research for patients with breast cancer.
Databáze: OpenAIRE
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