Effect of varicocelectomy on seminal plasma transferrin values: a comparative clinical trial
| Autor: | A. Koşar, Erol Özdiler, Kemal Sarica |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Urology Varicocele Semen Biology Andrology Endocrinology Internal medicine medicine Humans Sperm motility chemistry.chemical_classification Sertoli Cells Sperm Count Transferrin Case-control study Oligospermia General Medicine Sertoli cell medicine.disease Sperm medicine.anatomical_structure chemistry Case-Control Studies Sperm Motility |
| Zdroj: | Andrologia. 32:19-22 |
| ISSN: | 1439-0272 0303-4569 |
| Popis: | The possible effects of varicocele and of the varicocelectomy procedure on Sertoli cell function were investigated. Transferrin concentrations in seminal plasma in men with varicocele before and 3 months after the operation were evaluated. Concentrations were measured in 10 normozoospermic fertile men as a control group and 32 oligozoospermic men with varicocele. Also, sperm analysis before and 3 months after the operation was performed. The mean transferrin level in seminal plasma was 108.4 +/- 17.5 micrograms ml-1 in normoozoospermic men and 58.1 +/- 14.4 micrograms ml-1 in patients with varicocele before the operation (P < 0.0001). Mean sperm concentration, motility and normal morphology ratio showed significant improvement 3 months after the operation (P < 0.0001). Although the mean transferrin level increased slightly (to 60.8 +/- 16.2 micrograms ml-1; P = 0.2), there was a statistically significant correlation between the change in transferrin concentration and the change in sperm concentration after the operation (r = 0.56, P = 0.0008). These results showed that elevated transferrin secretion after the treatment seems to be associated with an increase in sperm concentration after varicocelectomy. The finding of improvements in seminal parameters after the operation but insignificant changes in seminal transferrin levels indicates that varicocelectomy results in a greater improvement in sperm quality than in Sertoli cell function. |
| Databáze: | OpenAIRE |
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