Microalbuminuria Is Acutely Increased during Anesthesia and Surgery
| Autor: | Jean Boulez, Christian Chery, Jean François Moskovtchenko, Pierre Sagnard, Etienne Tissot, Nicole Pozet, Alain Mercatello, A Hadj-Aissa |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty Vasopressin Kidney Glomerulus Renal function Vascular permeability urologic and male genital diseases Capillary Permeability Excretion Renin–angiotensin system Albuminuria Humans Medicine Anesthesia Intraoperative Complications Aged business.industry Albumin Middle Aged medicine.disease female genital diseases and pregnancy complications Surgery Female Microalbuminuria medicine.symptom business |
| Zdroj: | Nephron. 58:161-163 |
| ISSN: | 2235-3186 1660-8151 |
| DOI: | 10.1159/000186407 |
| Popis: | Microalbuminuria is known to increase in various diseases with potential repercussion on the kidneys and indicates an increase in glomerular intracapillary pressure or changes in permeability characteristics. In this study, we measured whether albumin excretion is affected in patients undergoing anesthesia and surgery, which are both known to induce dramatic changes in renal function and in the release of vasoactive substances such as catecholamines, vasopressin, angiotensin, and prostaglandins. Seven patients with normal renal function and physiological microalbuminuria prior to surgery were studied. Urine samples were collected before anesthesia, just before the beginning of surgery, and thereafter 30 min following incision, and 30 min after the end of surgery. Anesthesia induced a significant increase in microalbuminuria, which further increased during surgery. After the end of surgical procedure, microalbuminuria decreased but remained significantly higher than control. This phenomenon may be due to an increase in intracapillary glomerular pressure and/or an alteration in glomerular permeability induced by a direct effect of drugs, or to the action of vasoactive substances on the glomerular structure. |
| Databáze: | OpenAIRE |
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