Effects of melatonin supplementation on oxidative stress: a systematic review and meta-analysis of randomized controlled trials
| Autor: | Farhang Djafari, Sakineh Shab-Bidar, Aliyu Jibril Tijani, Fatemeh Sheikhhossein, Saba Mohammadpour, Parivash Ghorbaninejad |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Endocrinology
Diabetes and Metabolism Physiology 030204 cardiovascular system & hematology medicine.disease_cause Antioxidants law.invention Melatonin 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Randomized controlled trial law medicine Humans Molecular Biology Randomized Controlled Trials as Topic business.industry General Medicine Publication bias Malondialdehyde Oxidative Stress Antioxidant capacity chemistry Strictly standardized mean difference Meta-analysis Dietary Supplements business Biomarkers 030217 neurology & neurosurgery Oxidative stress medicine.drug |
| Zdroj: | Hormone Molecular Biology and Clinical Investigation. 41 |
| ISSN: | 1868-1891 1868-1883 |
| DOI: | 10.1515/hmbci-2020-0030 |
| Popis: | Objectives Previous studies showed that melatonin supplementation may suppress oxidative stress, however, the results have not been consistent. So, we conducted this meta-analysis to assess the precise relationship between melatonin supplementation and oxidative stress. Methods PubMed and Scopus were searched for randomized controlled trials that investigated the effect of melatonin supplementation on oxidative stress up to March 2020. Heterogeneity was assessed by Cochran’s Q test and I-square (I 2) statistic. Data were pooled using the random effect model and standardized mean difference (SMD) was considered as the summary effect size. Also, standard methods were used for assessment of sensitivity analysis and publication bias. Results We included 15 related articles and our findings indicated that melatonin supplementation significantly increased total antioxidant capacity (TAC) level (SMD: 1.03, 95% CI: 0.24, 1.81, p=0.011) and reduced protein carbonyl (PCO) (SMD: −1.78, 95% CI: −2.97, −0.58, p=0.004) and malondialdehyde (MDA) levels (SMD: −0.94, 95% CI: −1.48, −0.40, p=0.001). Additionally, there was considerable effect on TAC level by using ≥20 mg/d melatonin and in people under 35 years old. MDA level also decreased using dosage of below 20 mg/d and in people ≥35 years old. Conclusions The present study showed a promising effect of melatonin administration for reducing MDA, PCO, and increasing TAC levels. However, further studies especially with more attention to PCO level assessment are needed to confirm the findings of the present study in larger samples on different populations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|