Does Cyclosporin A Influence Sex Hormone Level?
| Autor: | Gebhart W, Schmidt Jb, H Kopsa, J Spona |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Hirsutism medicine.medical_specialty Adolescent Hydrocortisone Endocrinology Diabetes and Metabolism Cyclosporins Biology Endocrinology Sex hormone-binding globulin Sex Hormone-Binding Globulin Internal medicine Cyclosporin a Hydroxyprogesterones Internal Medicine medicine Humans Gonadal Steroid Hormones Testosterone hirsutism Estradiol 17-alpha-Hydroxyprogesterone General Medicine Middle Aged medicine.disease Prolactin Toxicity Androgens biology.protein Female Cortisone medicine.drug Hormone |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 88:207-211 |
| ISSN: | 1439-3646 0947-7349 |
| DOI: | 10.1055/s-0029-1210598 |
| Popis: | Cyclosporin A is an effective immunosuppressive substance which is extensively applied in various conditions. A well known side effect of high dose Cyclosporin A treatment is the occurrence of hypertrichosis, often referred to as hirsutism. The purpose of the study was therefore to investigate ovarian, adrenal and pituitary hormones as possible mediators of increased hair growth. In 5 female and 11 male patients who had developed hair overgrowth during Cyclosporin A treatment serum androgens (testosterone, dehydroepiandrosterone-sulfate, androstendione), sex hormone binding globuline (SHBG), prolactin (HPRL), 17-hydroxyprogesterone (17-OHP), 17 beta-estradiol (17 beta-E) and cortisol (F) were determined by standard radioimmunoassay methods. The same number of age matched patients with Azathioprine treatment served as control. Both patient groups received additive cortisone treatment of the same dosage. No significant differences of serum androgens were noted between Cyclosporin A treated patients and controls. In addition, normal prolactin levels were defected. 17-OHP was in the low normal range and cortisol below normal due to the additive cortisone treatment. SHBG was within normal range. The findings thus indicate that increased hair growth caused by Cyclosporin A seems not to be caused by an action of the substance on the hormonal level. |
| Databáze: | OpenAIRE |
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