Cholesterol efflux capacity does not associate with coronary calcium, plaque vulnerability, and telomere length in healthy octogenarians
| Autor: | Andrei C. Sposito, Franco Bernini, Ilaria Zanotti, Francesca Zimetti, Mauricio Daher, Wladimir M. Freitas, Maria Pia Adorni, Alessandra M. Campos |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty heart QD415-436 Coronary calcium 030204 cardiovascular system & hematology medicine.disease_cause Biochemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology High-density lipoprotein Risk Factors Internal medicine medicine Humans Aged 80 and over Cholesterol business.industry Cholesterol HDL aging vascular biology Cell Biology Telomere Vulnerable plaque Healthy Volunteers Plaque Atherosclerotic lipoproteins 030104 developmental biology chemistry Cardiovascular Diseases high density lipoprotein Cohort cardiovascular system Calcium Female Efflux atherosclerosis Patient-Oriented and Epidemiological Research business Biomarkers Calcium score |
| Zdroj: | Journal of Lipid Research, Vol 59, Iss 4, Pp 714-721 (2018) |
| ISSN: | 0022-2275 |
| DOI: | 10.1194/jlr.p079525 |
| Popis: | Several studies have revealed that traditional risk factors are less effective in predicting CVD risk in the elderly, suggesting the need to identify new biomarkers. Here, we evaluated the association between serum cholesterol efflux capacity (CEC), an atheroprotective property of HDL recently identified as a novel marker of CVD risk, and atherosclerotic burden in a cohort of very old, healthy individuals. Serum CEC values were not significantly correlated either with calcium score or with markers of vulnerable plaque, such as positive remodeling, hypodensity, spotty calcification, or napking-ring sign. In addition, no association was detected between CEC and telomere length, a marker of biological aging that has been linked to atherosclerosis extent. Interestingly, elderly subjects presented a remarkably higher CEC (+30.2%; P < 0.0001) compared with values obtained from a cohort of sex-matched, cardiovascular event-free, middle-aged individuals. In conclusion, serum CEC is not related to traditional risk factors in very old, cardiovascular event-free subjects, but has significantly higher values compared with a healthy, younger population. Whether this improved HDL functionality may represent a protective factor in CVD onset must be established in future studies. |
| Databáze: | OpenAIRE |
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