Topical application of a selective cyclooxygenase inhibitor suppresses UVB mediated cutaneous inflammation
| Autor: | Michelle L. Parrett, Traci A. Wilgus, Mary S. Ross, Tatiana M. Oberyszyn |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Physiology
Neutrophils Ultraviolet Rays Administration Topical Sunburn Human skin Inflammation Dermatitis Ibuprofen Pharmacology Biochemistry Dinoprostone Mice Edema medicine Animals Cyclooxygenase Inhibitors Prostaglandin E2 skin and connective tissue diseases Peroxidase Skin Mice Hairless Sulfonamides integumentary system biology Cyclooxygenase 2 Inhibitors business.industry Cell Biology medicine.disease Isoenzymes Celecoxib Cyclooxygenase 2 Prostaglandin-Endoperoxide Synthases Immunology biology.protein Pyrazoles Female Cyclooxygenase medicine.symptom Epidermis business Infiltration (medical) medicine.drug |
| Zdroj: | Prostaglandinsother lipid mediators. 62(4) |
| ISSN: | 1098-8823 |
| Popis: | Ultraviolet B (UVB) radiation causes much of the cutaneous damage after both acute and long-term exposure, and is also the most important etiologic agent in human skin cancer. UVB exposure initially induces an inflammatory response characterized by edema, dermal infiltration of leukocytes, sunburn cell formation, as well as the induction of cyclooxygenase-2 (COX-2) gene expression and subsequent increase in the production and release of prostaglandins. This process of inflammation induced by UVB exposure has been linked to tumor formation. Recently, a specific COX-2 inhibitor, Celecoxib, was developed, which inhibits COX-2-induced inflammation without inhibiting the cytoprotective function of cyclooxygenase-1 (COX-1). The present study compared the effects of topical treatment with Celecoxib (a specific COX-2 inhibitor) and Ibuprofen (a nonspecific COX inhibitor) on the acute UVB-induced cutaneous inflammatory response. We show that the specific inhibition of COX-2 effectively reduced many parameters of UVB-mediated inflammation, including edema, dermal neutrophil infiltration and activation, prostaglandin E2 (PGE2) levels and the formation of sunburn cells. By inhibiting this inflammatory response, topical Celecoxib treatment may ultimately be effective in preventing UVB-induced tumor development in the skin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect