Loss of Coordinated Neutrophil Responses to the Human Fungal Pathogen, Candida albicans, in Patients With Cirrhosis
| Autor: | Daniel Irimia, Nicolas Barros, Allison K. Scherer, Raymond T. Chung, Adam Viens, Natalie J. Alexander, Michael K. Mansour, Natalie J. Atallah, Zeina Dagher, Alex Hopke, Sally A.I. Knooihuizen |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Hyphal growth
Adult Liver Cirrhosis Male Cirrhosis Neutrophils medicine.medical_treatment Hyphae Proinflammatory cytokine White blood cell Candida albicans medicine Humans lcsh:RC799-869 Hepatology biology business.industry Candidiasis Immunity Original Articles Middle Aged medicine.disease biology.organism_classification Corpus albicans medicine.anatomical_structure Cytokine Case-Control Studies Immunology Cytokines lcsh:Diseases of the digestive system. Gastroenterology Original Article Female business Ex vivo |
| Zdroj: | Hepatology Communications Hepatology Communications, Vol 5, Iss 3, Pp 502-515 (2021) |
| ISSN: | 2471-254X |
| Popis: | Neutrophils are the most abundant white blood cell in the body and are key participants in the defense against fungal infections. Fungal infections occur often in patients with cirrhosis and are associated with increased 30‐day and 90‐day mortality. Previous studies have shown that specific neutrophil functions are abnormal in patients with cirrhosis, although the extent of neutrophil dysfunction is not well understood. We tested the ability of neutrophils from 21 hospitalized patients with cirrhosis and 23 healthy control patients to kill Candida albicans, a common fungal pathogen in patients with cirrhosis. Using an assay, we also measured the ability of neutrophils to coordinate multicellular, synchronized control of C. albicans hyphae through a process known as swarming. We found that neutrophils from patients with cirrhosis have significantly decreased fungicidal capacity compared with healthy control neutrophils (53% vs. 74%, P Neutrophils from patients with cirrhosis are defective in coordinated swarming response to the human fungal pathogen, Candida albicans. |
| Databáze: | OpenAIRE |
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