Lymphocytes from HIV-infected individuals show aberrant inositol polyphosphate metabolism which reverses after zidovudine therapy
| Autor: | Kirstine A. Knox, Anthony J. Pinching, Keith E. Nye |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
CD4-Positive T-Lymphocytes
Inositol Phosphates Lymphocyte Immunology HIV Infections Inositol 1 4 5-Trisphosphate Biology Lymphocyte Activation Phosphatidylinositols T-Lymphocytes Regulatory Interferon-gamma Leukocyte Count Zidovudine chemistry.chemical_compound medicine Humans Immunology and Allergy Inositol Lymphocytes Phosphatidylinositol Inositol phosphate chemistry.chemical_classification Acquired Immunodeficiency Syndrome Lymphoblast In vitro Infectious Diseases medicine.anatomical_structure chemistry Calcium Signal transduction medicine.drug |
| Zdroj: | Aids. 5:413-418 |
| ISSN: | 0269-9370 |
| DOI: | 10.1097/00002030-199104000-00009 |
| Popis: | Lymphocytes or lymphoblastoid cells that have been infected by HIV in vitro or exposed to its envelope glycoprotein (gp120) show abnormal inositol polyphosphate-mediated signal transduction and associated defects in calcium regulation. Such cells behave as though they were chronically activated and fail to respond to further activating signals. We now show that similar changes are seen in lymphocytes obtained from HIV-infected subjects at various stages of infection, despite the fact that only a minority of such cells are infected. Furthermore, the defect in the phosphatidylinositol hydrolysis pathway in lymphocytes obtained from AIDS patients reverses after treatment with zidovudine, in parallel with improvements in phytohaemagglutinin-induced proliferative response and interferon-gamma production. |
| Databáze: | OpenAIRE |
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