Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress

Autor:	Georgia E. Hodes, Sam A. Golden, Aditi Dey, Milo R. Smith, Jessica L. Ables, Hossein Aleyasin, Lena A. Khibnik, Nicole Rebusi, Kevin G. Guise, Gabriel A. Ben-Dor, Daniel J. Christoffel, Jessica J. Walsh, Mitra Heshmati, Madeline L. Pfau, Allyson K. Friedman, Robert C. Malenka, Matthew L. Shapiro, Inés Ibañez-Tallon, Karl Deisseroth, Ming-Hu Han, Scott J. Russo
Rok vydání:	2015
Předmět:	Male Dendritic spine Dendritic Spines Prefrontal Cortex Striatum Biology Medium spiny neuron Article Mice 03 medical and health sciences Glutamatergic 0302 clinical medicine Reward Thalamus Postsynaptic potential medicine Biological neural network Animals Social Behavior 030304 developmental biology 0303 health sciences Neuronal Plasticity Behavior Animal General Neuroscience Ventral striatum Excitatory Postsynaptic Potentials Mice Inbred C57BL medicine.anatomical_structure nervous system Ventral Striatum Excitatory postsynaptic potential Disease Susceptibility Neuroscience Stress Psychological 030217 neurology & neurosurgery
Zdroj:	Nature neuroscience
ISSN:	1546-1726 1097-6256
DOI:	10.1038/nn.4034
Popis:	Postsynaptic remodeling of glutamatergic synapses on ventral striatum (vSTR) medium spiny neurons (MSNs) is critical for shaping stress responses. However, it is unclear which presynaptic inputs are involved. Susceptible mice exhibited increased synaptic strength at intralaminar thalamus (ILT), but not prefrontal cortex (PFC), inputs to vSTR MSNs following chronic social stress. Modulation of ILT-vSTR versus PFC-vSTR neuronal activity differentially regulated dendritic spine plasticity and social avoidance.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::804af969368b4a6200dffe0ddad1398c https://doi.org/10.1038/nn.4034 Zobrazit plný text záznamu Plný text ve formátu PDF