Per-Particle Triglyceride-Rich Lipoproteins Imply Higher Myocardial Infarction Risk Than Low-Density Lipoproteins: Copenhagen General Population Study
| Autor: | George Davey Smith, Signe Vedel-Krogh, Sune F. Nielsen, Shoaib Afzal, Børge G. Nordestgaard, Mia Ø. Johansen |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Magnetic Resonance Spectroscopy Time Factors Denmark Myocardial Infarction 030204 cardiovascular system & hematology Lipoproteins VLDL Risk Assessment lipids 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Internal medicine medicine Low density Humans 030212 general & internal medicine Myocardial infarction Particle Size Stroke Triglycerides Aged Dyslipidemias Aged 80 and over Triglyceride business.industry Middle Aged medicine.disease Prognosis metabolomics stroke Lipoproteins LDL chemistry Lipoproteins IDL Heart Disease Risk Factors Apolipoprotein B-100 Cardiology Population study lipids (amino acids peptides and proteins) epidemiology Female Cardiology and Cardiovascular Medicine business apolipoproteins Biomarkers |
| Zdroj: | Johansen, M Ø, Vedel-Krogh, S, Nielsen, S F, Afzal, S, Davey Smith, G & Nordestgaard, B G 2021, ' Per particle triglyceride-rich lipoproteins imply higher myocardial infarction risk than low-density lipoproteins : Copenhagen General Population Study ', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 41, no. 6, pp. 2063-2075 . https://doi.org/10.1161/ATVBAHA.120.315639 Johansen, M, Vedel-Krogh, S, Nielsen, S F, Afzal, S, Smith, G D & Nordestgaard, B G 2021, ' Per-particle triglyceride-rich lipoproteins imply higher myocardial infarction risk than low-density lipoproteins copenhagen general population study ', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 41, pp. 2063-2075 . https://doi.org/10.1161/ATVBAHA.120.315639 |
| ISSN: | 1524-4636 |
| Popis: | Objective: ApoB (Apolipoprotein B)-containing triglyceride-rich lipoproteins and LDL (low-density lipoproteins) are each causal for myocardial infarction and atherosclerotic cardiovascular disease; however, the relative importance is unknown. We tested the hypothesis that for the same number of nonfasting apoB-containing particles from smaller LDL through to larger triglyceride-rich lipoproteins, the risk of myocardial infarction is similar. Approach and Results: We included 29 039 individuals with no history of myocardial infarction nested within 109 751 individuals from the Copenhagen General Population Study. Particle number of apoB-containing lipoprotein subfractions were measured using nuclear magnetic resonance spectroscopy. During a mean follow-up of 10 years, 2309 individuals developed myocardial infarction. Multivariable-adjusted hazard ratios for myocardial infarction per 1×10 15 particles were higher with larger size and more triglyceride content of apoB-containing lipoproteins using ten different subfractions, ranging from 11 (95% CI, 5.6–22) for extra extra large VLDL (very-low-density lipoproteins) to 1.06 (1.05–1.07) for extra small VLDL to 1.02 (1.01–1.02) for IDL (intermediate-density lipoproteins), through to 1.01 (1.01–1.01) for small LDL. When combining the particle number of 6 VLDL subfractions and combining IDL and 3 LDL subfractions, hazard ratios for myocardial infarction per 1×10 17 particles were 3.5 (2.7–4.5) for VLDL and 1.3 (1.2–1.4) for IDL and LDL combined. Conclusions: For the same number of apoB-containing particles (1×10 17 particles/L), the hazard ratio for myocardial infarction was 3.5-fold for VLDL and 1.3-fold for IDL and LDL combined. Biological implications include that VLDL particles are more atherogenic than LDL particles and clinically that VLDL and LDL should be measured separately. |
| Databáze: | OpenAIRE |
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