Pharmacokinetic studies in children with cancer

Autor: Ellis Groninger, Johannes H Proost, S.S.N. de Graaf
Přispěvatelé: Biopharmaceuticals, Discovery, Design and Delivery (BDDD), Faculty of Science and Engineering
Rok vydání: 2004
Předmět:
Drug
Oncology
medicine.medical_specialty
Metabolic Clearance Rate
media_common.quotation_subject
CELL LUNG-CANCER
CONTINUOUS-INFUSION ETOPOSIDE
Antineoplastic Agents
Pharmacology
anti-neoplastic drugs
PHASE-I TRIAL
Pharmacokinetics
individualized dosing
ACUTE LYMPHOCYTIC-LEUKEMIA
PEDIATRIC-ONCOLOGY-GROUP
Neoplasms
Internal medicine
medicine
pharmacodynamics
Humans
Dosing
Child
IMPAIRED RENAL-FUNCTION
Etoposide
media_common
ACUTE LYMPHOBLASTIC-LEUKEMIA
Dose-Response Relationship
Drug
ACUTE MYELOGENOUS LEUKEMIA
business.industry
Cancer
Immunotherapy
gene therapy and transplantation [UMCN 1.4]
Hematology
BONE-MARROW TRANSPLANTATION
medicine.disease
Therapeutic Equivalency
Pharmacodynamics
haematology
HIGH-DOSE METHOTREXATE
Methotrexate
pharmacokinetically guided
child oncology
business
pharmacokinetics
medicine.drug
Teniposide
Zdroj: Critical Reviews in Oncology/Hematology, 52(3), 173-197. ELSEVIER SCIENCE INC
Critical Reviews in Oncology Hematology, 52, 173-97
Critical Reviews in Oncology Hematology, 52, 3, pp. 173-97
ISSN: 1040-8428
Popis: Contains fulltext : 57123.pdf (Publisher’s version ) (Closed access) We reviewed the current status of our knowledge of pharmacokinetics and pharmacodynamics of some anti-neoplastic drugs, used in the treatment of childhood cancer. Extrapolation of data from pharmacokinetic studies in adults to the paediatric population is often not feasible. Specific studies in children are needed. Of all reviewed anti-neoplastic drugs methotrexate appears to be most extensively studied. Methotrexate pharmacokinetics is correlated with toxicity and response to therapy, and it has been shown that individualized adaptive dosing of methotrexate is correlated with a better response to therapy without increasing toxicity in children with ALL and osteosarcoma. Of most of the other reviewed anti-neoplastic drugs it is demonstrated that pharmacokinetics is correlated with toxicity, and of some drugs a relationship of pharmacokinetics with response to therapy is demonstrated as well. In case of cytarabine, etoposide, and teniposide, individualized dosing also appears to be feasible. However, there is no evidence that this strategy improves response to therapy. Specifically data on pharmacokinetic and pharmacodynamic correlations and effect of pharmacokinetically guided, individualized dosing are important for the design of optimal cancer chemotherapy for individual patients. Unfortunately for a considerable number of anti-neoplastic drugs these specific data are lacking in children and future research is needed.
Databáze: OpenAIRE
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