Human Immunodeficiency Virus Type 1 Infection in Women Attending a Sexually Transmitted Diseases Clinic in Kenya
| Autor: | Gregory B. Moss, Jackoniah O. Ndinya-Achola, Allan R. Ronald, Pierre J. Plourde, Francis A. Plummer, John Ombette, Elizabeth Agoki, Jacques Pépin, Mary Cheang, L J D'Costa |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Sexually transmitted disease medicine.medical_specialty Cross-sectional study Sexual Behavior Sexually Transmitted Diseases HIV Infections Disease Chancroid Acquired immunodeficiency syndrome (AIDS) Pregnancy Risk Factors Prevalence Humans Immunology and Allergy Medicine Marriage Pregnancy Complications Infectious Risk factor Ulcer Gynecology Contraceptive Devices Male business.industry Transmission (medicine) Obstetrics virus diseases medicine.disease Kenya Sex Work Genital ulcer Cross-Sectional Studies Sexual Partners Infectious Diseases Family planning HIV-1 Regression Analysis Female medicine.symptom business Genital Diseases Female Contraceptives Oral |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/166.1.86 |
| Popis: | A cross-sectional study of women attending a sexually transmitted diseases clinic in Nairobi Kenya was undertaken to determine the prevalence of and associated risk factors for HIV-1 infection. HIV-1 antibody was found in 13.8% of 600 women studied most frequently in prostitutes in women reporting histories of genital ulcers and in those with current diagnoses of genital ulcers. The high prevalence of HIV-1 infection was not confined among those identifying themselves as prostitutes. Seropositive women exhibited a significantly greater lifetime duration of oral contraceptive use. Through multivariate analysis the study found an association between genital ulcers and HIV-1 infection. No causal relationship between the 2 may however by deduced from this study. The strongest association for HIV-1 infection independent of sexual behavior was where genital ulcers combined with the use of oral contraceptives. Oral contraceptives may increase womens susceptibility to HIV-1 infection by increasing the area of cervical ectopy indirectly increasing the risk of C. trachomatis and/or by suppressing the immune system. While calculated attributable risks point to the strong role of prostitution and genital ulcer disease in facilitating heterosexual HIV-1 transmission in Nairobi prospective studies would help determine the risk of HIV-1 infection associated with the use of oral contraceptives. |
| Databáze: | OpenAIRE |
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