POSSIBLE BENEFICIAL EFFECTS OF VITAMIN K AND OSTEOCALCIN ON GLUCOSE METABOLISM
| Autor: | Busra Baspinar, Nurcan Yabanci Ayhan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Vitamin K biology business.industry glucose metabolism Vitamin K osteocalcin glucose metabolism type 2 diabetes insulin resistance osteocalcin Type 2 diabetes Vitamin k Carbohydrate metabolism medicine.disease Tıp Endocrinology Insulin resistance insulin resistance Internal medicine medicine Osteocalcin biology.protein Medicine type 2 diabetes business Beneficial effects |
| Zdroj: | Volume: 7, Issue: 2 106-113 Turkish Medical Student Journal |
| ISSN: | 2548-0030 2148-4724 |
| DOI: | 10.4274/tmsj.galenos.2020.07.02.08 |
| Popis: | DergiPark: 762687 tmsj The role of vitamin K, in bone metabolism and its effects on insulin resistance and Type-2 diabetes, have been discussed. The mechanism of vitamin K’s beneficial effect on insulin sensitivity and glucose homeostasis is not yet known. Various biological active molecules such as adiponectin, leptin, and resistin, which is secreted from adipose tissue and have important roles in glu- cose metabolism, have been proposed to regulate bone metabolism. Some studies have suggested that bone metabolism is also effective on adipose tissue and energy metabolism. It is thought that osteocalcin, a vitamin K dependent protein is effective in glucose metabolism. The role of Vitamin K in glucose metabolism is thought to be partly due to the modulation of diabetes-re- lated cytokines and other metabolic risk markers, as inflammation lies at the bottom of chronic metabolic diseases. The aim of this review is to explain the effect of Vitamin K and osteocalcin on glucose metabolism and its possible mechanisms of action. |
| Databáze: | OpenAIRE |
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