Histamine release from cord blood basophils is influenced by plasma IgE concentration, osmolarity, gestational age at birth and atopic disposition
| Autor: | Morten Hedegaard, T. Bjerke, B. W. Nielsen, Peter Oluf Schiøtz, Tine Brink Henriksen |
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| Rok vydání: | 1994 |
| Předmět: |
Hypersensitivity
Immediate Male medicine.medical_specialty Immunology Population Stimulation Gestational Age Basophil In Vitro Techniques Immunoglobulin E Histamine Release chemistry.chemical_compound Internal medicine Immunology and Allergy Medicine Humans education education.field_of_study biology Osmotic concentration business.industry Osmolar Concentration Infant Newborn Fetal Blood Basophils Immunoglobulin A Endocrinology medicine.anatomical_structure chemistry Concanavalin A Cord blood Pediatrics Perinatology and Child Health biology.protein Female business Histamine |
| Zdroj: | Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. 5(4) |
| ISSN: | 0905-6157 |
| Popis: | To characterize the normal values of histamine release from basophil leucocytes in cord blood after stimulation with both IgE-mediating and non-IgE-mediating secretagogues, a population of 1,684 newborn infants was studied using a microfiber-based method for detecting histamine release. A wide variation in anti-IgE and Concanavalin A-induced histamine release in the population was found. An increase in osmolarity in the release media selectively enhanced the maximal IgE-mediated histamine release, in addition to an increase in sensitivity in the dose response for anti-IgE and Concanavalin A. Both anti-IgE and Concanavalin A mediated histamine release were found to be significantly associated with the concentration of IgE in cord blood. Furthermore, an increased sensitivity to the IgE-mediated response and a close correlation between anti-IgE and Concanavalin A histamine release were found in the group of newborns with high IgE levels. Gestational age at birth and histamine release after stimulation with both IgE-mediating, and non-IgE mediating secretagogues were found to be significantly related, thus suggesting a continuing maturation of the human basophil leucocytes in the last weeks of gestation. Parental atopic disposition also affected basophil releasability in cord blood. |
| Databáze: | OpenAIRE |
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