Genetic progression of post-transplant Burkitt-like lymphoma case with 11q-Gain/Loss and MYC amplification
| Autor: | Grzegorz Rymkiewicz, Natalia Malawska, Jolanta Rygier, Barbara Pienkowska-Grela, Zbigniew Bystydzienski, Beata Nowakowska, Anita Borysiuk, Katarzyna Blachnio, Renata Woroniecka, Beata Grygalewicz |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Cancer Research Clone (cell biology) Biology Proto-Oncogene Proteins c-myc 03 medical and health sciences 0302 clinical medicine immune system diseases hemic and lymphatic diseases microRNA Genetics medicine Humans Molecular Biology Gene 11q Aberration Chromosome Aberrations Chromosomes Human Pair 11 Gene Amplification medicine.disease Burkitt Lymphoma Kidney Transplantation Post transplant Lymphoma Gene expression profiling 030220 oncology & carcinogenesis Cancer research Kidney Failure Chronic MYC Amplification |
| Zdroj: | Cancer genetics. 245 |
| ISSN: | 2210-7762 |
| Popis: | "Burkitt-like lymphoma with 11q aberration" is a new provisional entity in the latest revision of lymphoma's World Health Organization classification described as carrying the specific 11q-gain/loss aberration and lacking MYC rearrangement. Morphologically, phenotypically and by gene and microRNA expression profiling these lymphomas resemble Burkitt lymphoma. The 11q-gain/loss was also found in post-transplant patients with molecular Burkitt lymphoma signature without MYC rearrangement. Recent reports describe aggressive lymphomas with coexistence of 11q-gain/loss and MYC rearrangement. In this report we describe post-transplant Burkitt-like lymphoma with 11q aberration and MYC amplification. Genetic studies were conducted at two time points: before therapy and during progression. In both cytogenetic examinations, peculiar 11q-gain/loss was detected. Percentage of cells carrying MYC amplification increased from 2% at initial diagnosis to 97% during progression. The MYC amplification can functionally correspond to MYC translocation and to MYC overexpression. The presence of MYC amplification seems to increase the aggressiveness of the reported disease course, so even a small clone with this change should be indicated in cytogenetic result. |
| Databáze: | OpenAIRE |
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