Initiation of GnRH agonist treatment on 3-5 days postoperatively in endometriosis patients: a randomized controlled trial
| Autor: | Lili Gong, Shien Zou, Qiqi Long, Yi Han, Yuankui Cao, Shao-fen Zhang |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty Visual analogue scale Urology Endometriosis Drug Administration Schedule law.invention Menstruation Gonadotropin-Releasing Hormone Follicle-stimulating hormone Young Adult Randomized controlled trial Bleeding time law medicine Humans Pharmacology (medical) Postoperative Period Pharmacology medicine.diagnostic_test Estradiol business.industry Goserelin Luteinizing Hormone Middle Aged medicine.disease Surgery Female Uterine Hemorrhage Follicle Stimulating Hormone Luteinizing hormone business medicine.drug |
| Zdroj: | Journal of clinical pharmacology. 55(8) |
| ISSN: | 1552-4604 |
| Popis: | Seventy patients with stage III or IV endometriosis were randomly assigned to 2 groups after conservative surgery. Group O (n = 35) received 3 cycles of a 28-day gonadotropin-releasing hormone agonist (GnRH-a) treatment (goserelin, 3.6 mg) starting 3-5 days postoperatively. Group M (n = 35) received the same treatment starting on days 1-5 of menstruation. Groups were further subdivided according to add-back treatment. Pre- and posttreated levels of estradiol (E2 ), follicle stimulating hormone (FSH), and luteinizing hormone (LH) and visual analog scale (VAS), Kupperman menopausal index (KMI), and bone mineral density (BMD) scores were recorded. The incidence of uterine bleeding was assessed. In both groups, serum levels of E2 , FSH, and LH and VAS scores decreased significantly after treatment. Spotting was the most frequent bleeding pattern. During cycle 1, the bleeding time in group M was much longer that than that in group O (P =.001), and the bleeding rate in group M was significantly higher than that in group O (P =.024, RR = 1.185). In patients with stage III or IV endometriosis, the efficacy of GnRH-a initiated 3-5 days postoperatively was equivalent to that of GnRH-a initiated on days 1-5 of menstruation. Female patients who initiated GnRH-a treatment 3-5 days postoperatively experienced less uterine bleeding during the first cycle of treatment. |
| Databáze: | OpenAIRE |
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