Investigation of coffee in sister chromatid exchange and micronucleus tests in vivo
| Autor: | H. Meier, E. Ruch, H.U. Aeschbacher, H.P. Würzner |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Cell Nucleus
Male Genetics Mutagenicity Tests business.industry Sister chromatid exchange General Medicine Pharmacology Toxicology Body weight Coffee Single oral dose Mice Cricetulus In vivo Cricetinae Micronucleus test Animals Sister chromatids Medicine business Sister Chromatid Exchange Mutagens Food Science |
| Zdroj: | Food and Chemical Toxicology. 22:803-807 |
| ISSN: | 0278-6915 |
| DOI: | 10.1016/0278-6915(84)90118-2 |
| Popis: | Administration of a single oral dose of instant coffee to Chinese hamsters at levels up to 2.5 g/kg body weight did not increase the frequency of sister chromatid exchanges. Furthermore, five consecutive daily oral doses of instant coffee given to Swiss OF-1 mice up to 3 g/kg/day did not induce increases in micronuclei above spontaneous levels. Similarly, no effect was observed in the micronucleus test after mice received two oral doses of coffee aroma of up to 50 ml/kg. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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