Asymmetric Synthesis of 1,2-Dihydronaphthalene-1-ols via Copper-Catalyzed Intramolecular Reductive Cyclization
| Autor: | Ranjan Kumar Acharyya, Yeji Park, Jaesook Yun, SoYoung Kim, Jung Tae Han |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Ketone 010405 organic chemistry Chemistry Organic Chemistry Enantioselective synthesis 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Intramolecular force Copper catalyzed Moiety Physical and Theoretical Chemistry |
| Zdroj: | Organic letters. 22(20) |
| ISSN: | 1523-7052 |
| Popis: | We describe a copper-catalyzed intramolecular reductive cyclization of easily accessible benz-tethered 1,3-dienes containing a ketone moiety. This process provided biologically active 1,2-dihydronaphthalene-1-ol derivatives in good yields with excellent enantio- and diastereoselectivity. Mechanistic investigations using density functional theory revealed that ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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