Neolignans from Selaginella moellendorffii
| Autor: | Jun Yang, Xing-Li Su, Ren-Qiang Mei, Yue-Hu Wang, Jing-Xian Zhuo, Yi Kong, Chunlin Long |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Selaginellaceae
Platelet aggregation Stereochemistry Pharmacology toxicology Plant Science Toxicology 01 natural sciences Biochemistry Lignans Analytical Chemistry chemistry.chemical_compound Selaginella moellendorffii Antiplatelet Benzofuran Pharmacology biology 010405 organic chemistry Alkaloid Organic Chemistry biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Plant biochemistry Original Article Flavanone Food Science |
| Zdroj: | Natural Products and Bioprospecting |
| ISSN: | 2192-2209 2192-2195 |
| Popis: | Two new neolignans selaginellol (1) and selaginellol 4′-O-β-d-glucopyranoside (2), together with seven known compounds (3–9), were isolated from the whole plant of Selaginella moellendorffii. The structures of the new isolates were determined through spectroscopic data analysis. Compounds 1–9, as well as compounds 10–18 previously isolated from the species, were measured for the activity against platelet aggregation induced by ADP or collagen. Three neoligans (8, 11, and 12), one flavanone (14), and one alkaloid (16) showed inhibitory activity against ADP- or collagen-induced platelet aggregation as compared with tirofiban. The dihydrobenzofuran neolignans (8, 11, and 12) are more potent than the benzofuran neolignan (13) and other types of neolignans (1–7). Glucosidation of the dihydrobenzofuran neolignans (11 and 12) is helpful for the activity. Graphical Abstract Two new neolignans selaginellol (1) and selaginellol 4′-O-β-d-glucopyranoside (2) were isolated from the whole plant of Selaginella moellendorffii. Several compounds from this plant showed the activity against platelet aggregation induced by ADP or collagen. Electronic supplementary material The online version of this article (doi:10.1007/s13659-016-0095-5) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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