Asymptomatic Atypical Hyperplasia and Endometriosis Following Treatment with Tamoxifen: A Case Report and Review of the Literature
| Autor: | Sarah Alghamdi, Lea Luketic, Mackenzie Grisdale, Odette Boutross-Tadross |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Endometriosis Urology Breast Neoplasms Hysterectomy Endometrium Asymptomatic Atypical hyperplasia Malignant transformation 03 medical and health sciences 0302 clinical medicine Breast cancer Humans Medicine 030212 general & internal medicine skin and connective tissue diseases Laparoscopy Ultrasonography Hyperplasia 030219 obstetrics & reproductive medicine medicine.diagnostic_test business.industry Obstetrics and Gynecology Middle Aged medicine.disease Tamoxifen medicine.anatomical_structure Female medicine.symptom business medicine.drug |
| Zdroj: | Journal of Obstetrics and Gynaecology Canada. 43:85-87 |
| ISSN: | 1701-2163 |
| DOI: | 10.1016/j.jogc.2020.04.018 |
| Popis: | Background Tamoxifen may cause proliferative effects in the endometrium. Patients on tamoxifen have an increased risk for endometriosis, but are not routinely screened for this. Case A 49-year-old postmenopausal patient presented for a total laparoscopic hysterectomy and bilateral salpingo-oophorectomy several years after initiating tamoxifen for breast cancer. She had no clinical history to suggest endometriosis, but was found to have extensive pelvic endometriosis intraoperatively with polypoid hyperplasia found on the pathology of the uterine and the ovarian tissue. Conclusion This is the first case reported of an asymptomatic patient on tamoxifen with a new diagnosis of endometriosis along with atypical hyperplasia in the ectopic tissue. The potential for pre-malignant/malignant transformation may alter the treatment course if identified following tamoxifen exposure. |
| Databáze: | OpenAIRE |
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