Randomized clinical trial on seven-day-per-week continuous accelerated irradiation for patients with esophageal carcinoma: Preliminary report on tumor response and acute toxicity
| Autor: | Tao Ye, Ya-Zhou Liu, Hai-Ting Xu, Suping Sun, Wei-Dong Wang, Jing-Lei Shi, Wen Zhang, Wen-Bin Shen |
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| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Esophageal Neoplasms Treatment outcome Tumor response Gastroenterology law.invention Hemoglobins Randomized controlled trial law Preliminary report Internal medicine Carcinoma medicine Humans Radiation Injuries Aged Aged 80 and over business.industry Dose fractionation Dose-Response Relationship Radiation General Medicine Middle Aged medicine.disease Acute toxicity Surgery Blood Cell Count Treatment Outcome Female Dose Fractionation Radiation business Rapid Communication |
| Popis: | Tumor response and normal tissue toxicity of seven-day-per-week continuous accelerated irradiation (CAIR) for patients with esophageal carcinoma were evaluated and compared to conventional irradiation (CR).Sixty patients with squamous cell carcinoma of the esophagus were randomized into two groups: the CAIR group (30 patients) and the CR group (30 patients). Patients in the CAIR group received radiotherapy (RT) with 2 Gy/fraction per day at 7 d/wk with a total dose of 50-70 Gy (average dose 64.2 Gy). The overall time of irradiation was 3.6-5.0 wk (average 4.6 wk). RT in the CR group was 2 Gy/fraction per day at 5 d/wk with a total dose of 40-70 Gy (average dose 61.7 Gy). The overall time of irradiation was 4.0-7.0 wk (average 6.4 wk).The data showed that the immediate tumor response to RT was better in the CAIR group than in the CR group. Efficiency rates (CR plus PR) were 82.8% (24/29) and 58.6% (17/29), respectively (P = 0.047). In both groups the incidences of esophagitis and tracheitis were insignificant (P = 0.376, 0.959), and no patient received toxicity that could not be tolerated.CAIR shortens overall treatment time and is well tolerated by patients. It may be superior to CR in enhancing the local response of tumor, but its remote effect for esophageal carcinoma awaits further follow-up. |
| Databáze: | OpenAIRE |
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