Introduction of a novel quantitative scoring system for acanthosis nigricans and its validation in a pilot study
| Autor: | Emin Ozlu, Remzi Karadag, Tugba Kevser Uzuncakmak, WenChieh Chen, Mehmet Simsek, Mumtaz Takir, Necmettin Akdeniz, Osman Kostek, Ayse Serap Karadag, Uwe Wollina |
|---|---|
| Přispěvatelé: | [Belirlenecek] |
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Multiple Skin Tags Waist Adolescent body mass index Pilot Projects Dermatology Community Gastroenterology Severity of Illness Index Association 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Insulin resistance Hyperpigmentation Internal medicine Diabetes mellitus insulin resistance medicine Prevalence Diabetes Mellitus Outpatient clinic Humans Acanthosis Nigricans Obesity Prospective Studies Prospective cohort study Acanthosis nigricans Aged Skin tags business.industry Insulin-Resistance General Medicine medicine.disease 030220 oncology & carcinogenesis business American Body mass index Diabetes Risk-Factors |
| Zdroj: | Dermatologic therapyREFERENCES. 33(6) |
| ISSN: | 1529-8019 |
| Popis: | Inconsistent data exist regarding the diagnostic value of acanthosis nigricans (AN) or skin tags as clinical markers for obesity or diabetes. In an outpatient department-based prospective study, we designed a scoring for AN severity (SCANS) to evaluate AN and skin tags, their correlation with obesity or diabetes. Quantification of AN in six anatomic sites, in consideration of the affected skin surface areas, texture changes, number of skin tags, leads to a total severity score between 0 and 46. Among 336 adult patients (aged >= 18 years) with AN, a higher BMI was associated with AN (r = 0.299, P < .001), but not with diabetes (P = .43), as compared with 243 age- and sex-matched controls without AN. Among nondiabetics, AN scores were significantly correlated with waist circumference (r = 0.131, P = .024) and total cholesterol levels (r = 0.155, P = .04). Skin tags alone in the absence of AN were not associated with obesity (P = .333) or diabetes (P = .164). The total AN scores were positively correlated with the presence of skin tags (r = 0.132, P < .001), and the involvement of anterior neck (r = 0.668, P < .001) and axilla (r = 0.793, P < .001). Knuckles and groins were unaffected in our series. Our results indicate that combination of AN with skin tags can be used as clinical marker for obesity, but not for diabetes. Large-scale studies on patients of different ethnic background are required to further validate our proposed scoring. WOS:000586721100001 2-s2.0-85096708449 PubMed: 33103332 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|