Serum neutrophil gelatinase-associated lipocalin as a marker of renal function in children with chronic kidney disease
| Autor: | Jonathan Barasch, Philip R. Khoury, Thomas L. Nickolas, Jaya Mishra, Thelma Kathman, Prasad Devarajan, Janis Kartal, Mark Mitsnefes |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Nephrology medicine.medical_specialty Adolescent Urology Contrast Media Renal function Pilot Projects Kidney urologic and male genital diseases End stage renal disease Lipocalin-2 Proto-Oncogene Proteins Triiodobenzoic Acids Internal medicine medicine Humans Prospective Studies Cystatin C Child reproductive and urinary physiology biology business.industry Acute kidney injury medicine.disease Cystatins Lipocalins female genital diseases and pregnancy complications Cross-Sectional Studies Chronic Disease Pediatrics Perinatology and Child Health biology.protein Biomarker (medicine) Female Kidney Diseases Cystatin business Biomarkers Acute-Phase Proteins Glomerular Filtration Rate Kidney disease |
| Zdroj: | Pediatric Nephrology. 22:101-108 |
| ISSN: | 1432-198X 0931-041X |
| DOI: | 10.1007/s00467-006-0244-x |
| Popis: | Very few biomarkers exist for monitoring chronic kidney disease (CKD). We have recently shown that serum neutrophil gelatinase-associated lipocalin (NGAL) represents a novel biomarker for early identification of acute kidney injury. In this study, we hypothesized that serum NGAL may also represent a biomarker for the quantitation of CKD. Forty-five children with CKD stages 2-4 were prospectively recruited for measurement of serum NGAL, serum cystatin C, glomerular filtration rate (GFR) by Ioversol clearance, and estimated GFR (eGFR) by Schwartz formula. Serum NGAL significantly correlated with cystatin C (r=0.74, P0.000). Both NGAL and cystatin C significantly correlated with measured GFR (r=0.62, P0.000; and r=0.71, P0.000, respectively) as well as with eGFR (r=0.66, P0.000 and r=0.59, P0.000, respectively). At GFR levels ofor=30 ml/min per 1.73 m(2), serum NGAL, cystatin C, and eGFR were all significantly correlated with measured GFR. However, in subjects with lower GFRs (30 ml/min per 1.73 m(2)), serum NGAL levels correlated best with measured GFR (r=0.62), followed by cystatin C (r=0.41). We conclude that (a) both serum NGAL and cystatin C may prove useful in the quantitation of CKD, and (b) by correlation analysis, NGAL outperforms cystatin C and eGFR at lower levels of measured GFR. |
| Databáze: | OpenAIRE |
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